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miR-7 reduces high glucose induced-damage via HoxB3 and PI3K/AKT/mTOR signaling pathways in retinal pigment epithelial cells.

08:00 EDT 23rd October 2019 | BioPortfolio

Summary of "miR-7 reduces high glucose induced-damage via HoxB3 and PI3K/AKT/mTOR signaling pathways in retinal pigment epithelial cells."

Diabetic retinopathy (DR) is a common complication of diabetes. This study investigated the effect of miR-7 on the regulation of cell proliferation via the HoxB3 gene and PI3K/AKT/mTOR signaling pathways in DR. Methods:Human retinal pigment epithelial cell line (ARPE-19) cultured in normal medium (Control) and high glucose medium (25mM glucose, HG) was transfected with mimics NC (HG+ mimics NC), miR-7 mimics (HG+miR-7 mimics), inhibitor NC (HG+ inhibitor NC), and miR-inhibitor (HG+miR-7 inhibitor). The cells were assayed for viability, apoptosis and expression of genes.

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This article was published in the following journal.

Name: Current molecular medicine
ISSN: 1875-5666
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