Effects of morphine on interstitial cells of Cajal in rabbit colon and small intestinal transit: An experimental study.

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Summary of "Effects of morphine on interstitial cells of Cajal in rabbit colon and small intestinal transit: An experimental study."

Diabetic retinopathy (DR) is a common complication of diabetes. This study investigated the effect of miR-7 on the regulation of cell proliferation via the HoxB3 gene and PI3K/AKT/mTOR signaling pathways in DR. Methods:Human retinal pigment epithelial cell line (ARPE-19) cultured in normal medium (Control) and high glucose medium (25mM glucose, HG) was transfected with mimics NC (HG+ mimics NC), miR-7 mimics (HG+miR-7 mimics), inhibitor NC (HG+ inhibitor NC), and miR-inhibitor (HG+miR-7 inhibitor). The cells were assayed for viability, apoptosis and expression of genes.


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This article was published in the following journal.

Name: Current molecular medicine
ISSN: 1875-5666


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Medical and Biotech [MESH] Definitions

c-Kit positive cells related to smooth muscle cells that are intercalated between the autonomic nerves and the effector smooth muscle cells of the gastrointestinal tract. Different phenotypic classes play roles as pacemakers, mediators of neural inputs, and mechanosensors.

An anoctamin chloride channel expressed at high levels in the liver, skeletal muscle, and gastrointestinal muscles that functions in transepithelial anion transport and smooth muscle contraction. It is essential for the function of the INTERSTITIAL CELLS OF CAJAL and plays a major role in chloride conduction by airway epithelial cells and in tracheal cartilage development.

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.


Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced.

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