Possible Pathways of Hepatotoxicity Caused by Chemical Agents.

07:00 EST 5th November 2019 | BioPortfolio

Summary of "Possible Pathways of Hepatotoxicity Caused by Chemical Agents."

Liver injury induced by drugs has become a basic reason for acute liver disease and therefore posed a potential regulatory and clinical challenge over the past few decades and has received greater attention. It also remains the most common cause of failure of drugs during clinical trials. In 50% of all acute liver failure cases, drug-induced hepatoxicity is the primary factor and 5% of all hospital admissions Methods: The various hepatotoxins which are used to induce hepatotoxicity in experimental animals include paracetamol, CCl4, isoniazid, thioacetamide, erythromycin, diclofenac, alcohol, etc. Among the various models used to induce hepatotoxicity in rats, every hepatotoxin causes toxicity by different mechanisms.


Journal Details

This article was published in the following journal.

Name: Current drug metabolism
ISSN: 1875-5453


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