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Higher Atazanavir plasma exposure in Rats is associated with Gut Microbiota Changes induced by Cotrimoxazole.

08:00 EDT 22nd October 2019 | BioPortfolio

Summary of "Higher Atazanavir plasma exposure in Rats is associated with Gut Microbiota Changes induced by Cotrimoxazole."

Cotrimoxazole (TMP-SMX) is concomitantly used as primary prophylaxis of opportunistic infections with antiretroviral agents such as Atazanavir (ATV). Results from an ex vivo study showed changes in intestinal absorption of ATV when rats were pretreated with TMP-SMX. The objective of this in vivo study is to determine the effect of TMP-SMX on the pharmacokinetics of ATV in rats. We also studied changes in gut microbiota induced by TMP-SMX.

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Name: Current drug metabolism
ISSN: 1875-5453
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