The importance of amide protons in peptide drug development.

07:00 EST 8th November 2019 | BioPortfolio

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Name: Future medicinal chemistry
ISSN: 1756-8927


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Medical and Biotech [MESH] Definitions

A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems.

DNA analogs containing neutral amide backbone linkages composed of aminoethyl glycine units instead of the usual phosphodiester linkage of deoxyribose groups. Peptide nucleic acids have high biological stability and higher affinity for complementary DNA or RNA sequences than analogous DNA oligomers.

Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. EC 6.3.1.

The octapeptide amide of bovine angiotensin II used to increase blood pressure by vasoconstriction.

Measurable biological parameters that serve for drug development, safety and dosing (DRUG MONITORING).

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