Copper-Catalyzed Cascade Cyclization of Arylsulfonylhydrazones Derived from -Alkynyl Arylketones: Regioselective Synthesis of Functionalized Cinnolines.

07:00 EST 11th November 2019 | BioPortfolio

Summary of "Copper-Catalyzed Cascade Cyclization of Arylsulfonylhydrazones Derived from -Alkynyl Arylketones: Regioselective Synthesis of Functionalized Cinnolines."

A novel copper-catalyzed cascade reaction of arylsulfonylhydrazones derived from -alkynyl arylketones was accomplished. This reaction provides concise access to diversified cinnolines in good yields. The mechanistic investigations have disclosed involvement of the key alkynyl amination, 1,4-aryl migration, desulfonylation, and diazo radical cyclization cascade in the transformation.


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Name: Organic letters
ISSN: 1523-7052


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