Topics

Sensitization of hypoxic tumor to photodynamic therapy via oxygen self-supply of fluorinated photosensitizers.

07:00 EST 11th November 2019 | BioPortfolio

Summary of "Sensitization of hypoxic tumor to photodynamic therapy via oxygen self-supply of fluorinated photosensitizers."

Photodynamic therapy (PDT) utilizes photosensitizers to convert innoxious oxygen to cytotoxic reactive oxygen species under an appropriate light thus induce cancer cells necrosis. However, PDT performs in an oxygen-dependent method to destroy cells while hypoxia is a feature for most solid tumors. To effectively improve the PDT effect against solid tumors, an oxygen self-supplying and pH-sensitive therapeutic nanoparticle (PTFC) has been developed by the self-assembly of a tetrakis(pentafluorophenyl) chlorin (TFPC)-conjugated block copolymer (POEGMA-b-P(DEAEMA-co-GMA)). PTFC nanoparticles can transport oxygen to tumor site with their accumulation in tumor on account of the good oxygen solubility, therefore relieving the oxygen deficiency of solid tumor and enhancing the PDT efficacy. It's worth noting that the oxygen loading was realized by fluorinated photosensitizer itself. In addition, the phototoxicity of PTFC nanoparticles is greatly improved in an acidic aqueous environment due to the DEAEMA unit protonation, which not only enhanced the cellular uptake of nanoparticles but also weakened the aggregation of photosensitizers. Taking the hypoxia and acidic microenvironment of solid tumors, PTFC nanoparticles could be efficiently taken up and disassembled to release oxygen upon accumulated at tumor sites, thus significantly improving the PDT efficacy against solid tumors.

Affiliation

Journal Details

This article was published in the following journal.

Name: Biomacromolecules
ISSN: 1526-4602
Pages:

Links

DeepDyve research library

PubMed Articles [18960 Associated PubMed Articles listed on BioPortfolio]

In situ Oxygen Evolving Photoactive Nano-Cocktail: Future of the Hypoxic Tumor Photodynamic Therapy.

Hypoxia related resistance is one of the main challenges for photodynamic therapy to overcome. This highlight discusses a few current works on possible ways to overcome this problem by in situ oxygen ...

Multi-Path Tumor Inhibition via the Interactive Effects between a Tumor Microenvironment and an Oxygen Self-Supplying Delivery System for a Photosensitizer.

The tumor microenvironment (TME) affects not only tumor growth and metastasis, but also therapy efficacy. In the present study, an oxygen self-supplying delivery system for a photosensitizer (O-PDS), ...

Size-Switchable Nanoparticles with Self-Destructive and Tumor Penetration Characteristics for Site-Specific Phototherapy of Cancer.

The normoxic and hypoxic microenvironments in solid tumors cause cancer cells to show different sensitivities to various treatments. Therefore, it is essential to develop different therapeutic modalit...

Remodeling extracellular matrix based on functional covalent organic framework to enhance tumor photodynamic therapy.

Photodynamic therapy (PDT) is a promising treatment modality for tumor suppression. However, the hypoxic state of most solid tumors might largely hinder the efficacy of PDT. Here, a functional covalen...

Glutathione depletion and dual-model oxygen balance disruption for photodynamic therapy enhancement.

Photodynamic therapy (PDT) is a prospective approach to cure tumor diseases. However, tumor micro-environment is notably characterized with severe hypoxia and high expression of glutathione (GSH), whi...

Clinical Trials [11266 Associated Clinical Trials listed on BioPortfolio]

Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy

The purpose of this study is to to evaluate the safety and efficacy of hyperbaric oxygen in term gestation newborn infants with hypoxic-ischemic encephalopathy..

Assessment of Portable Oxygen Concentrators in Infants Undergoing Hypoxic Challenge Testing.

Hypoxic Challenge Testing (HCT) is the recommended method for inflight hypoxia risk assessment. Onboard oxygen administration remains controversial. The Federal Aviation Administration app...

Nocturnal Oxygen Therapy

To compare the efficacy of long-term use of nocturnal oxygen therapy (12 hours) with that of continuous, low-flow oxygen therapy (24 hours) in patients with chronic hypoxic lung disease.

S-1 and Photodynamic Therapy in Cholangiocarcinoma

In patients with type III or IV cholangiocarcinoma, photodynamic therapy with biliary stent has been known for palliation of jaundice and improving survival. But most of therapeutic effect...

Photodynamic Therapy Plus Brachytherapy in Treating Patients With Lung Cancer

RATIONALE: Photodynamic therapy uses light and drugs that make cnacer cells more sensitive to light to kill tumor cells. Brachytherapy uses radiation to damage tumor cells. Photodynamic th...

Medical and Biotech [MESH] Definitions

Hypoxic conditions in tumor cells due to the tumor outgrowing its blood supply. It is associated with increased METASTASIS and resistance to RADIOTHERAPY and DRUG THERAPY.

The purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States.

A nitroimidazole that sensitizes hypoxic tumor cells that are normally resistant to radiation therapy.

A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.

A complex mixture of monomeric and aggregated porphyrins used in the photodynamic therapy of tumors (HEMATOPORPHYRIN PHOTORADIATION). A purified component of this mixture is known as DIHEMATOPORPHYRIN ETHER.

Quick Search


DeepDyve research library

Relevant Topic

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...


Searches Linking to this Article