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Conditional Survival and Recurrence of Remnant Gastric Cancer After Surgical Resection: A Multi-institutional Study.

07:00 EST 11th November 2019 | BioPortfolio

Summary of "Conditional Survival and Recurrence of Remnant Gastric Cancer After Surgical Resection: A Multi-institutional Study."

This study was designed to evaluate the dynamic survival and recurrence of remnant gastric cancer (RGC) after radical resection and to provide a reference for the development of personalized follow-up strategies. A total of 298 patients were analysed for their 3-year conditional overall survival (COS3), 3-year conditional disease-specific survival (CDSS3), corresponding recurrence and pattern changes, and associated risk factors. The 5-year OS and the 5-year DSS of the entire cohort were 41.2% and 45.8%, respectively. The COS3 and CDDS3 of RGC patients who survived for 5 years were 84.0% and 89.8%, respectively. The conditional survival in patients with unfavourable prognostic characteristics showed greater growth over time than in those with favourable prognostic characteristics (e.g., COS3, ≥T3: 46.4%-83.0%, Δ36.6% vs. ≤T2: 82.4%-85.7%, Δ3.3%; p<0.001). Most recurrences (93.5%) occurred in the first 3 years after surgery. The AJCC stage was the only factor that affected recurrence. Time-dependent Cox regression showed that for both OS and DSS, after 4 years of survival, the common prognostic factors that were initially judged lost their ability to predict survival (p >0.05). Time-dependent logistic regression analysis showed that the AJCC stage independently affected recurrence within two years after surgery (p < 0.05). A postoperative follow-up model was developed for RGC patients. In conclusion, patients with RGC usually have a high likelihood of death or recurrence within 3 years after radical surgery. we developed a postoperative follow-up model for RGC patients of different stages, which may affect the design of future clinical trials.

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Name: Cancer science
ISSN: 1349-7006
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Medical and Biotech [MESH] Definitions

That portion of the stomach remaining after gastric surgery, usually gastrectomy or gastroenterostomy for cancer of the stomach or peptic ulcer. It is a common site of cancer referred to as stump cancer or carcinoma of the gastric stump.

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Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)

Surgical procedure in which the STOMACH is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the SMALL INTESTINE by an end-to-side SURGICAL ANASTOMOSIS, depending on the amounts of intestinal surface being bypasses. This procedure is used frequently in the treatment of MORBID OBESITY by limiting the size of functional STOMACH, food intake, and food absorption.

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