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Prolonged ethanol administration prevents the development of tolerance to morphine-induced respiratory depression.

08:00 EDT 30th October 2019 | BioPortfolio

Summary of "Prolonged ethanol administration prevents the development of tolerance to morphine-induced respiratory depression."

Opioid users regularly consume other drugs such as alcohol (ethanol). Acute administration of ethanol can rapidly reverse tolerance to morphine-induced respiratory depression. However, alcohol consumption by opioid users is likely to occur over prolonged time periods. We have therefore sought to determine the effect of prolonged alcohol consumption on the development of tolerance to opioid respiratory depression.

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This article was published in the following journal.

Name: Drug and alcohol dependence
ISSN: 1879-0046
Pages: 107674

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Medical and Biotech [MESH] Definitions

A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration.

Administration of low doses of a drug or a drug combination over prolonged periods of time usually at a regular interval.

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The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

A potent inhibitor of membrane metalloendopeptidase (ENKEPHALINASE). Thiorphan potentiates morphine-induced ANALGESIA and attenuates naloxone-precipitated withdrawal symptoms.

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