Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in Dystrophic Mice Ameliorated by Oral L-arginine Supplementation.

07:00 EST 13th November 2019 | BioPortfolio

Summary of "Spatiotemporal Mapping Reveals Regional Gastrointestinal Dysfunction in Dystrophic Mice Ameliorated by Oral L-arginine Supplementation."

Patients with Duchenne muscular dystrophy exhibit significant, ongoing impairments in gastrointestinal (GI) function likely resulting from dysregulated nitric oxide production. Compounds increasing neuronal nitric oxide synthase expression and/or activity could improve GI dysfunction and enhance quality of life for dystrophic patients. We used video imaging and spatiotemporal mapping to identify GI dysfunction in dystrophic mice and determine whether dietary intervention to enhance nitric oxide could alleviate aberrant colonic activity in muscular dystrophy.


Journal Details

This article was published in the following journal.

Name: Journal of neurogastroenterology and motility
ISSN: 2093-0879


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Muscular Dystrophy
Muscular dystrophy is a group of degenerative inherited disorders causing muscle weakness and loss of muscle tissue. The different types are Becker muscular dystrophy, Duchenne muscular dystrophy, Emery-Dreifuss muscular dystrophy, Facioscapulohumeral mu...

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