Standardized L. Extract Increases Exercise Endurance Through Stimulation of Mitochondrial Biogenesis.

08:00 EDT 1st November 2019 | BioPortfolio

Summary of "Standardized L. Extract Increases Exercise Endurance Through Stimulation of Mitochondrial Biogenesis."

has been reported to exhibit anti-allergic, anti-infertility, anti-inflammatory, anti-rheumatic, and immunosuppressive activities. However, there are very few studies describing its stimulatory effects on exercise capacity. This study elucidated whether extract (SOE) standardized to kirenol content can enhance exercise endurance by increasing mitochondrial biogenesis. SOE significantly improved the running distance and time in mice fed normal diet (ND) and high-fat diet (HFD). SOE also enhanced mitochondrial biogenesis by stimulating the mitochondrial regulatory genes including peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1), estrogen-related receptor (ERR), nuclear respiratory factor 1 (NRF-1), and mitochondrial transcription factor A (TFAM) in the skeletal muscles of ND and HFD mice. Furthermore, SOE upregulated the AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/PGC-1/peroxisome proliferator-activated receptor delta (PPAR) signaling pathway in the skeletal muscles of ND and HFD mice. Kirenol markedly increased adenosine triphosphate production and mitochondrial activity by stimulating the expression of markers of mitochondrial biogenesis and upregulating the AMPK/SIRT1/PGC-1/PPAR signaling pathway in L6 myotubes. These results show that SOE has the potential to be used to develop an exercise supplement capable of stimulating mitochondrial biogenesis through the AMPK/SIRT1/PGC-1/PPAR signaling pathway.


Journal Details

This article was published in the following journal.

Name: Journal of medicinal food
ISSN: 1557-7600
Pages: 1159-1167


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Medical and Biotech [MESH] Definitions

The exercise capacity of an individual as measured by endurance (maximal exercise duration and/or maximal attained work load) during an EXERCISE TEST.

A plant genus of the family ARALIACEAE. Ciwujia extract, which is prepared from plants of this genus, contains ciwujianosides and is used to enhance PHYSICAL ENDURANCE.

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Standardized terms used in the nursing field (e.g., NURSING INFORMATICS).

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