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Malignant tumor has been always endangering human health, and its morbidity and mortality have been increasing year by year. At present, the main clinical treatment of malignant tumors is surgery, radiotherapy and chemotherapy, but it is difficult to achieve satisfactory prognosis. In recent years, targeted therapy for various tumors has been more and more popular. Molecular targeted drugs are mainly targeted at key targets in the development of malignant tumors. Some molecular targeted drugs have shown good results in the corresponding tumor treatment. More and more molecular targeted drugs have been developed and produced due to the well understanding of the molecular targets and involved pathways of tumorigenesis and development. In this review, we will summarize the direct targets of western medicine targeted drugs and traditional Chinese medicine monomers, as well the study methods about molecular targets. The purpose of this review is to seek the best ways to find out the targets and pathways of the active ingredients of traditional Chinese medicine by referring to the research methods of western medicine.
This article was published in the following journal.
Name: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Advances in genomic technologies and the development of targeted therapeutics are making the use of precision medicine increasingly possible. In this study, we explored whether precision medicine can ...
The WEE1 inhibitor adavosertib (AZD1775) has been investigated in Western patients.
: Treatment of rheumatic diseases has been greatly advanced by the introduction of biological molecular-targeted therapies. However, owing to their high heterogeneity at the molecular and clinical lev...
Gastrointestinal stromal tumors (GISTs) are rare soft tissue sarcomas of the gastrointestinal tract, with most carrying conserved driver mutations in the tyrosine kinase receptors KIT or PDGFRα. The ...
Embryonal brain tumors (EBTs) are highly aggressive malignancies predominantly affecting children. They include medulloblastoma (MB), atypical rhabdoid/teratoid tumors (ATRT), pineoblastoma (PB), embr...
This is a prospective study to identify molecular mechanisms of acquired resistance to targeted therapies in patients with unresectable or metastatic cancer. This is a protocol to study c...
This is a pilot biomarker study designed to compare frequencies of mutations between groups of malignant, benign and normal tissue or blood of patients with parathyroid disease and identif...
This study is a prospective, preliminary evaluation of the efficacy of the integration of Traditional Chinese medicine (TCM) and western medicine based on TCM syndrome differentiation. The...
In the light of the development of high-throughput technologies enabling a biology-based reclassification of tumors and the increasing number of available specifically targeting anticancer...
Breast cancer is one of the most serious threat to women's health of malignant tumors, also the most common causes of cancer death in women.Triple-negative breast cancer (TNBC) refers to t...
The field of medicine concerned with understanding the biochemical basis of health and disease and involved in developing diagnostic and therapeutic methods that utilize MOLECULAR BIOLOGY techniques.
Antibodies, often monoclonal, in which the two antigen-binding sites are specific for separate ANTIGENIC DETERMINANTS. They are artificial antibodies produced by chemical crosslinking, fusion of HYBRIDOMA cells, or by molecular genetic techniques. They function as the main mediators of targeted cellular cytotoxicity and have been shown to be efficient in the targeting of drugs, toxins, radiolabeled haptens, and effector cells to diseased tissue, primarily tumors.
A historical and cultural entity dispersed across the wide geographical area of Europe, as opposed to the East, Asia, and Africa. The term was used by scholars through the late medieval period. Thereafter, with the impact of colonialism and the transmission of cultures, Western World was sometimes expanded to include the Americas. (Dr. James H. Cassedy, NLM History of Medicine Division)
The study and practice of medicine by direct examination of the patient.
A technique for causing a targeted loss of molecular function from REACTIVE OXYGEN SPECIES that are formed by the illumination of dyes placed in the immediate vicinity of the target molecule.
Complementary and Alternative Medicine
Alternative medicine are whole medical systems that did not fit with conventional medicine as they have completely different philosophies and ideas on the causes of disease, methods of diagnosis and approaches to treatment. Although often overlapping, co...
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...