Development of a d-allose-6-phosphate derivative with anti-proliferative activity against a human leukemia MOLT-4F cell line.
Summary of "Development of a d-allose-6-phosphate derivative with anti-proliferative activity against a human leukemia MOLT-4F cell line."
d-Allose, a C-3 epimer of d-glucose, is a naturally occurring rare monosaccharide that shows anti-proliferative activity against several human cancer cell lines. However, d-allose requires a relatively high concentration for the activity to be observed. Thus, developing more potent derivatives is needed for application. In cells, d-allose is converted to d-allose-6-phosphate (A6P), which is responsible for the anti-proliferative activity of d-allose. In this study, we synthesized A6P derivative 1 with biodegradable protecting groups, which showed higher anti-proliferative activity than A6P against a MOLT-4F human leukemia cell line. Similarly protected derivative of d-glucose-6-phosphate (G6P) (2) and tetraacetyl-A6P (3) showed weaker and less activity compared with 1, respectively, suggesting that both A6P moiety and the protecting group on the phosphate group are responsible for the activity. In addition, significantly weaker induction of thioredoxin-interacting protein (TXNIP) expression by 1 compared with d-allose suggests that 1 exhibited cytotoxicity through the synergetic effect of inducing TXNIP expression and other mechanisms.
Affiliation
Journal Details
This article was published in the following journal.
Name: Carbohydrate research
ISSN: 1873-426X
Pages: 107859
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/31751780
- DOI: http://dx.doi.org/10.1016/j.carres.2019.107859
PubMed Articles
Searching for diagnostic properties of novel fluorine-18-labeled D-allose.
Two fluorine-18-labeled analogues, 3-deoxy-3-[F]fluoro-D-allose (3-[F]FDA) and 6-deoxy-6-[F]fluoro-D-allose (6-[F]FDA), were synthesized and their potentials of diagnostic property were characterized.
Anti-oxidative and anti-proliferative activities of extracted phytochemical compound thymoquinone.
To evaluate the anti-oxidant and anti-proliferative potential of Thymoquinone extracted from the essential oil of indigenous herbs of Nigella sativa and Thymus vulgaris.
The progression of cancer through local expansion and metastasis is well recognized, but preventing these characteristic cancer processes is challenging. To this end, a new strategy is required. In th...
A novel indole derivative (N-(1H-2-phenyl-indole-3-ylmethyl) acrylamide, NPI) synthesized by a Friedel-Crafts alkylation reaction was identified using IR spectroscopy, H NMR, C NMR and elemental analy...
T-Cell Engagers Based Bioassay for Evaluation of PD-1/PD-L1 Inhibitors Activity.
PD-1/PD-L1-based therapy has been named a revolution in cancer treatment. By the end of 2018, more than 100 anti-PD-1 and anti-PD-L1 antibodies were in various stages of development, and more than 200...
Clinical Trials
The Impact of a Low or High Phosphate Diet on Phosphate and Calcium Excretion in Healthy People
Phosphate is present in many of the foods that the investigators eat and is required by many cellular processes. The kidneys are the only organ that excrete the extra phosphate from the di...
This is a prospective cohort study, open-label, uncontrolled proof of concept trial. The trial objective is to evaluate the analgesic tolerability, safety and activity of IDN 5243 (3-glyco...
Meat Derivative and Satiating Compound Effect on Satiety
The purpose of this study is to evaluate the satiating effects of a meat derivative and a satiating compound on overweight subjects (BMI ≥25 and
Regenerative Combined Therapy With Enamel Matrix Derivative and Biphasic Calcium Phosphate Graft
Background: The use of Enamel Matrix Derivative (EMD) when dealing with non-contained defects may be limited, as EMD does not maintain a space itself. It has been proposed the use of combi...
Certain percent of the eyes with proliferative diabetic retinopathymay require pars plana vitrectomy (PPV) due to vitreous haemorrhage, proliferative membrane, and tractional retinal detac...
Medical and Biotech [MESH] Definitions
Betamethasone Valerate
The 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity.
Betamethasone 17-valerate
The 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity.
Canrenoic Acid
A synthetic pregnadiene derivative with anti-aldosterone activity.
Canrenoate Potassium
A synthetic pregnadiene derivative with anti-aldosterone activity.
Ketorolac Tromethamine
A pyrrolizine carboxylic acid derivative structurally related to INDOMETHACIN. It is a non-steroidal anti-inflammatory agent used for analgesia for postoperative pain and inhibits cyclooxygenase activity.
Quick Links
Advanced Search |
Login |
Subscribe |
RSS 
Relevant Topics
Leukemia
Leukemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases. In turn, it is part of the even broader grou...
Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...
BioPortfolio Twitter Channels (200+ Accounts)
LinkedIn