Role of Co-stimulatory Molecules in T Helper Cell Differentiation.

07:00 EST 1st January 2019 | BioPortfolio

Summary of "Role of Co-stimulatory Molecules in T Helper Cell Differentiation."

CD4 T cells play a central role in orchestrating the immune response to a variety of pathogens but also regulate autoimmune responses, asthma, allergic responses, as well as tumor immunity. To cover this broad spectrum of responses, naïve CD4 T cells differentiate into one of several lineages of T helper cells, including Th1, Th2, Th17, and T, as defined by their cytokine pattern and function. The fate decision of T helper cell differentiation integrates signals delivered through the T cell receptor, cytokine receptors, and the pattern of co-stimulatory signals received. In this review, we summarize the contribution of co-stimulatory and co-inhibitory receptors to the differentiation and maintenance of T helper cell responses.


Journal Details

This article was published in the following journal.

Name: Advances in experimental medicine and biology
ISSN: 0065-2598
Pages: 153-177


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