The impact of body composition parameters on severe toxicity of nivolumab.
Summary of "The impact of body composition parameters on severe toxicity of nivolumab."
The occurrence of severe, acute limiting toxicity in patients receiving anti-programmed cell death receptor-1 monoclonal antibodies, such as nivolumab, is largely unpredictable. Sarcopenia was found to be associated with anti-cytotoxic T-lymphocyte-associated protein 4 acute toxicity. We explore the clinical and pharmacological parameters influencing nivolumab toxicity, including body composition.
Affiliation
Journal Details
This article was published in the following journal.
Name: European journal of cancer (Oxford, England : 1990)
ISSN: 1879-0852
Pages: 170-177
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/31794927
- DOI: http://dx.doi.org/10.1016/j.ejca.2019.11.003
PubMed Articles
Nivolumab is an immune checkpoint inhibitor specific to the programmed death 1 (PD-1) receptor. Nivolumab has shown clinical responses in many malignancies. Although immune-related adverse events (irA...
Among younger men, lower body mass is associated with fewer urinary symptoms, including incontinence and nocturia. However, lower body mass may have different implications for older men due to age-ass...
We report a 57-year-old woman with stage IIIb melanoma of unknown primary in the right groin negative for BRAF receiving for six months adjuvant nivolumab infusions every other week (3 mg per kilogram...
Body Composition in Patients with Congenital Myotonic Dystrophy.
Congenital myotonic dystrophy (CDM) is a rare neuromuscular disorder characterized by severe hypotonia and muscle weakness at birth that tends to improve with age. Understanding lean body and bone mas...
Acute and 28-day repeated dose oral toxicity study of caraway oil in rats.
Background Caraway oil (CO) obtained from the fruits of Carum carvi L. (Apiaceae) is used in traditional systems of medicine for various diseases. The present study was designed to evaluate the safety...
Clinical Trials
18F-PD-L1 PET/CT in Nivolumab Treated Patients With NSCLC
A multicenter single arm biomarker exploration and validation study. Eighty patients with NSCLC that are eligible for nivolumab treatment according to EMA label and national guidelines wil...
Impact of Currently Recommended Postnatal Nutrition on Neonatal Body Composition
The purpose of this study is to gain information that may be useful in helping to figure out better or newer ways to provide nutrition to babies born premature.
Whole Body Vibration Training on Body Composition
The purpose of the study is to determine the effect of whole-body vibration (WBV) on body composition, physical fitness, and quality of life.
A Phase 1, Bioavailability Study of Relatlimab in Combination With Nivolumab
This study will characterize the movement of drugs within the body, evaluate safety and determine to which extent the body can process relatlimab in combination with nivolumab in subjects ...
Randomized Study of Nivolumab+Ipilimumab+/- SBRT for Metastatic Merkel Cell Carcinoma
The purpose of this study is to test the effectiveness, safety, and tolerability of the drugs nivolumab plus ipilimumab with or without the addition of stereotactic body radiation therapy ...
Medical and Biotech [MESH] Definitions
Body Composition
The relative amounts of various components in the body, such as percentage of body fat.
Thermodynamics
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Physostigmine
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
Likelihood Functions
Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.
Toxicity Tests
An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.
Quick Links
Advanced Search |
Login |
Subscribe |
RSS 
Relevant Topics
Monoclonal antibodies MAbs
Monoclonal antibodies recognise and attach to specific proteins produced by cells.
Types of monoclonal antibodies used to treat cancer cells:
Block cell dividing dividing signals
Transport cancer drugs or radiation to cancer cells
Tr...
Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
BioPortfolio Twitter Channels (200+ Accounts)
LinkedIn