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Pulmonary toxicity of FeO, ZnFeO, NiFeO and NiZnFeO nanomaterials: Inflammation and DNA strand breaks.

07:00 EST 21st November 2019 | BioPortfolio

Summary of "Pulmonary toxicity of FeO, ZnFeO, NiFeO and NiZnFeO nanomaterials: Inflammation and DNA strand breaks."

Exposure to metal oxide nanomaterials potentially occurs at the workplace. We investigated the toxicity of two Fe-oxides: FeO nanoparticles and nanorods; and three MFeO spinels: NiZnFeO, ZnFeO, and NiFeO nanoparticles. Mice were dosed 14, 43 or 128 μg by intratracheal instillation. Recovery periods were 1, 3, or 28 days. Inflammation - neutrophil influx into bronchoalveolar lavage (BAL) fluid - occurred for FeO rods (1 day), ZnFeO (1, 3 days), NiFeO (1, 3, 28 days), FeO (28 days) and NiZnFeO (28 days). Conversion of mass-dose into specific surface-area-dose showed that inflammation correlated with deposited surface area and consequently, all these nanomaterials belong to the so-called low-solubility, low-toxicity class. Increased levels of DNA strand breaks were observed for both FeO particles and rods, in BAL cells three days post-exposure. To our knowledge, this is, besides magnetite (FeO), the first study of the pulmonary toxicity of MFeO spinel nanomaterials.

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This article was published in the following journal.

Name: Environmental toxicology and pharmacology
ISSN: 1872-7077
Pages: 103303

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