Phyllanthus emblica fruit extract attenuates lipid metabolism in 3T3-L1 adipocytes via activating apoptosis mediated cell death.

08:00 EDT 31st October 2019 | BioPortfolio

Summary of "Phyllanthus emblica fruit extract attenuates lipid metabolism in 3T3-L1 adipocytes via activating apoptosis mediated cell death."

Phyllanthus emblica L. (Indian gooseberry) is widely used in the Ayurveda for thousands of years to treat health complications including disorders of the immune system, diabetes, and obesity.


Journal Details

This article was published in the following journal.

Name: Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Pages: 153129


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Medical and Biotech [MESH] Definitions

A plant species of the family EUPHORBIACEAE.

A family of vertebrate and insect lipid droplet associated proteins. They consist of a conserved N-terminal PAT domain (an alpha-helical region of about 110 amino acids), an 11-mer repeat region, and lipid-binding hydrophobic regions or 4-helix bundles near their C-termini. Perilipins transiently or constitutively localize to LIPID DROPLETS in ADIPOCYTES and FOAM CELLS, especially in regions adjacent to the PLASMA MEMBRANE and ENDOPLASMIC RECTICULUM. They are critical for lipid droplet synthesis and homeostasis as well as the regulation of lipid metabolism. Genetic variations in perilipins are associated with ATHEROSCLEROSIS; OBESITY; and DIABETES MELLITUS.

Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.

Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.

A perilipin protein characterized by an extensive 11-mer repeat region, which forms five adjacent alpha-helices. It is expressed primarily in WHITE ADIPOSE TISSUE and differentiating ADIPOCYTES, as well as skeletal muscle and heart. It is soluble in the cytoplasm but re-localizes to the surface of LIPID DROPLETS under high lipid conditions.

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