Loss of Setd4 delays radiation-induced thymic lymphoma in mice.

07:00 EST 25th November 2019 | BioPortfolio

Summary of "Loss of Setd4 delays radiation-induced thymic lymphoma in mice."

Radiation-induced lymphomagenesis results from a clonogenic lymphoid cell proliferation due to genetic alterations and immunological dysregulation. Mouse models had been successfully used to identify risk and protective factors for radiation-induced DNA damage and carcinogenesis. The mammalian SETD4 is a poorly understood putative methyl-transferase. Here, we report that conditional Setd4 deletion in adult mice significantly extended the survival of radiation-induced T-lymphoma. However, in Tp53 deficient mice, Setd4 deletion did not delay the radiation-induced lymphomagenesis although it accelerated the spontaneous T-lymphomagenesis in non-irradiated mice. The T-lymphomas were largely clonogenic in both Setd4 and Setd4 mice based on sequencing analysis of the T-cell antigen β receptors. However, the Setd4 T-lymphomas were CD4/CD8 double positive, while the littermate Setd4tumor were largely CD8+ single positive. A genomic sequencing analysis on chromosome deletion, inversion, duplication, and translocation, revealed a larger contribution of inversion but a less contribution of deletion to the overall chromosome rearrangements in the in Setd4 tumors than the Setd4 tumors. In addition, the Setd4 mice died more often from the large sizes of primary thymus lymphoma at earlier time, but there was a slight increase of lymphoma dissemination among peripheral organs in Setd4 at later times. These results suggest that Setd4 has a critical role in modulating lymphomagenesis and may be targeted to suppress radiation-induced carcinogenesis.


Journal Details

This article was published in the following journal.

Name: DNA repair
ISSN: 1568-7856
Pages: 102754


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