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c-Jun N-terminal kinases (JNKs) and p38s are central components of signal transduction pathways, which are stimulated mainly by environmental stress and inflammatory cytokines. Manipulation of JNK and p38 dependent immune responses either boosts or subdues immune responses to infectious diseases or inflammatory disorders. In this study, we analyzed the whole-genome database of the grass carp and identified 4 JNK and 6 p38 genes. JNK and p38 genes of grass carp were distributed in 7 out of 24 chromosomes. All JNK and p38 proteins contained characteristic dual-phosphorylation site. The JNKs contain a specific dual-phosphorylation consensus ((Thr-Pro-Tyr) that is different from that of the p38 proteins (Thr-Gly-Tyr). Deduced gene secondary structure analyses as well as the syntenic analyses further supported their annotation and orthologs. Results of tissue distribution detection revealed that JNK and p38 genes exhibited lower expression in health grass carp. The mRNA expression levels of JNK and p38 genes were significantly up-regulated in tissues and CIK cells after bacterial infection, indicating their potential roles in bacterial-regulated immune responses. These findings in our study will facilitate the further evolutionary characterization of JNK and p38 genes in teleost species and provide a theoretical basis for their functional study.
This article was published in the following journal.
Name: Comparative biochemistry and physiology. Part D, Genomics & proteomics
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To reveal the genetic determinants of the treatment outcome of escitalopram in depressed patients (by using candidate gene approach and whole genome scanning).
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An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
A bacteriophage genus of the family LEVIVIRIDAE, whose viruses contain the short version of the genome and have a separate gene for cell lysis.
A bacteriophage genus of the family LEVIVIRIDAE, whose viruses contain the longer version of the genome and have no separate cell lysis gene.
The complete gene complement contained in a set of chromosomes in a fungus.
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports research into the mapping of the human genome and other organism genomes. The National Center for Human Genome Research was established in 1989 and re-named the National Human Genome Research Institute in 1997.
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
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