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Chemical liver and kidney injury have become a serious concern to human. Side effects occur when they are treated with medicine. The present study evaluated the preventive effect of Cyclocarya paliurus polysaccharides (CP) on hepatic and renal injury in carbon tetrachloride (CCl) induced mice. The results showed that CP treatment could effectively prevent HO-induced oxidative damage of NCTC-1469 cells. Administrated with CP could ameliorate the body weight loss and organ swelling of mice induced by the 0.2% CCl. Compared with the model group, CP groups have beneficial effects in decreasing ALT, AST, TBA and CRE levels in serum. In addition, the expression of CYP2E1 in the liver was also significantly decline after continuous administration of CP. Moreover, pre-administration of CP can improve the antioxidant status of liver and kidney (MDA and SOD, GSH-Px). Histopathological studies also supported the improvement of CP on liver and kidney of CCl-induced mice. These results indicate that CP may be of therapeutic value in ameliorating the hepatic and renal oxidative stress caused by CCl, through its antioxidant properties.
This article was published in the following journal.
Name: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.
A radiation-protective agent that interferes with sulfhydryl enzymes. It may also protect against carbon tetrachloride liver damage.
A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2.
A potent liver poison. In rats, bromotrichloromethane produces about three times the degree of liver microsomal lipid peroxidation as does carbon tetrachloride.
A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)
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