Track topics on Twitter Track topics that are important to you
Tablet quality can be affected by material, configuration and design of the tooling which comprise punches and dies. Much research attention had centred around punches, with very little reported on the dies. Dies with modified bore lining materials or inserts are available for special applications. However, the influence of such die types on tablet properties and the compaction process has not been well studied. Often, the reason for selecting dies with harder lining material is for improved wear resistance. In this study, flat-faced and convex-faced tablets were produced from paracetamol granules using dies with different bore inserts. Tablet properties and response parameters of the compaction process were evaluated to understand the impact of die mechanical and surface properties on the compacts formed. Compaction pressure was found to have the greatest impact on tablet elastic recovery (r ≥ 0.96, p < 0.01 in all bivariate correlations) and thus affecting the tensile strength. Choice of die inserts could impact the mechanical properties of convex-faced paracetamol tablets, particularly at high compaction pressures.
This article was published in the following journal.
Name: International journal of pharmaceutics
Press-coating (also called compression coating or dry coating) consists of a second compression of an outer layer of material over a preformed tablet core. Despite being old, this technology has retur...
Tablets are a complex drug delivery system consisting of the active pharmaceutical ingredients and excipients. Tablet production involves a series of unit operations in which drugs and excipients are ...
The primary plant cell wall is a dynamically regulated composite material of multiple biopolymers that forms a scaffold enclosing the plant cells. The mechanochemical make-up of this polymer network r...
The plant cell wall is a dynamic structure that mediates cell and organ morphogenesis and provides structural support to the whole plant body. The primary load bearing components of the cell wall are ...
The subdivision behavior of polymeric tablets produced with the well-known polymers Soluplus (SOL), polyvinyl pyrrolidone co-vinyl acetate (PVPVA) and hydroxypropyl methylcellulose (HPMC) was evaluate...
The sponsor, Pfizer has developed a formulation of tramadol hydrochloride/ paracetamol 37.5 mg/ 325 mg (test drug) as a generic alternative to the reference listed product Ultracet®. In o...
Eligible subjects in this study will have either a known abdominal aortic aneurysm (AAA) or because they do not have an AAA (control group). The purpose of this research study is to furth...
This study is designed to assess bioequivalence between two paracetamol/ phenylephrine combination products.
The purpose of this study is to measure the mechanical properties of healing Achilles tendons in humans after early controlled weightbearing, compared with a control group in a randomized,...
When restoring teeth with IPS Empress laminate veneers, fracture of restorations may occur. So, material with higher mechanical properties is required. Celtra Duo is a new material with gl...
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
A technique of measuring the dielectric properties of materials, which vary over a range of frequencies depending on the physical properties of the material. The technique involves measuring, over a range of frequencies, ELECTRICAL IMPEDANCE and phase shift of an electric field as it passes through the material.
Measurement of the temperature of a material, or of the body or an organ by various temperature sensing devices which measure changes in properties of the material that vary with temperature, such as ELASTICITY; MAGNETIC FIELDS; or LUMINESCENCE.
The processes and properties of living organisms by which they take in and balance the use of nutritive materials for energy, heat production, or building material for the growth, maintenance, or repair of tissues and the nutritive properties of FOOD.
The properties and processes of materials that affect their behavior under force.