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Impact of Die Wall Material on the Mechanical Properties of Paracetamol Tablets.

07:00 EST 30th November 2019 | BioPortfolio

Summary of "Impact of Die Wall Material on the Mechanical Properties of Paracetamol Tablets."

Tablet quality can be affected by material, configuration and design of the tooling which comprise punches and dies. Much research attention had centred around punches, with very little reported on the dies. Dies with modified bore lining materials or inserts are available for special applications. However, the influence of such die types on tablet properties and the compaction process has not been well studied. Often, the reason for selecting dies with harder lining material is for improved wear resistance. In this study, flat-faced and convex-faced tablets were produced from paracetamol granules using dies with different bore inserts. Tablet properties and response parameters of the compaction process were evaluated to understand the impact of die mechanical and surface properties on the compacts formed. Compaction pressure was found to have the greatest impact on tablet elastic recovery (r ≥ 0.96, p < 0.01 in all bivariate correlations) and thus affecting the tensile strength. Choice of die inserts could impact the mechanical properties of convex-faced paracetamol tablets, particularly at high compaction pressures.

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This article was published in the following journal.

Name: International journal of pharmaceutics
ISSN: 1873-3476
Pages: 118902

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