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Epilepsy is a circuit-level brain disorder characterized by excessive or hypersynchronous epileptic seizures involving a complex epileptogenic network. Cumulative evidence suggests that the piriform cortex (PC) is a crucial site in seizure initiation, propagation, and generalization in epilepsy. The kindling model is a classic animal model of complex partial seizures with secondarily generalized tonic seizures, which is usually used for the study of epilepsy pathogenesis and preclinical anti-epilepsy drug evaluation. Various essential functions of the PC in epilepsy were discovered in the kindling model, therefore, this review focuses on discussing the role of the PC in the kindling model. We review what pathological changes happen in the PC in the kindling model, how the PC is involved in the kindling model through different interventions, and finally we also provide perspectives on some possible research directions for future studies.
This article was published in the following journal.
Name: Experimental neurology
The piriform cortex is a distinct brain region that plays a key role in the sense of smell. The piriform cortex is the major part of primary olfactory cortex and has broad connections that extend beyo...
The objective of the study were to investigate patterns of multiunit cluster firing in the piriform cortex (PC) and mediodorsal thalamus (MDT) in a rat model of genetic generalized epilepsy (GGE) with...
The objective of the study was to quantify effective connectivity from the piriform cortex to mediodorsal thalamus, in Genetic Absence Epilepsy Rats from Strasbourg (GAERS).
Deep brain stimulation (DBS) may help control seizures in individuals with medically intractable epilepsy who are not candidates for resective surgery. The current review focuses on some preclinical s...
Epilepsy is a chronic and severe neurological disorder. Phosphatase and tensin homolog deleted on chromosome ten (PTEN)-deficient mice exhibit learning and memory deficits and spontaneous epilepsy. Th...
Transcranial Magnetic Stimulation (TMS) is a non-invasive technique that can be used to stimulate brain activity and gather information about brain function. It is very useful when studyi...
Background: Epilepsy affects about 1 percent of the U.S. population. Most people with epilepsy respond well to medicine, but some do not. Researchers want people who have diagnosed or sus...
The goal of the present clinical trial is to determine whether low frequency (.5 Hz) rTMS can induce long term depression in epileptogenic cortex and thus suppress cortical excitability at...
People with epilepsy often experience problems with their memories and other thinking skills that get worse over time. The investigators hope to learn more about whether a drug called mem...
The purpose of this research study to investigate, classify, and quantify chronic cardiac rhythm disorders in three groups of patients with epilepsy (intractable focal epilepsy, controlled...
An area of the olfactory cortex comprising the rostral half of the uncus of the PARAHIPPOCAMPAL GYRUS and the anterior PARAHIPPOCAMPAL GYRUS. It receives major afferents directly from the OLFACTORY BULB.
The rostral part of the amygdala with cortical-like layered structure. It receives major inputs from the OLFACTORY BULB and PIRIFORM CORTEX.
The inability to recognize a familiar face or to learn to recognize new faces. This visual agnosia is most often associated with lesions involving the junctional regions between the temporal and occipital lobes. The majority of cases are associated with bilateral lesions, however unilateral damage to the right occipito-temporal cortex has also been associated with this condition. (From Cortex 1995 Jun;31(2):317-29)
A neurosurgical procedure that removes the anterior TEMPORAL LOBE including the medial temporal structures of CEREBRAL CORTEX; AMYGDALA; HIPPOCAMPUS; and the adjacent PARAHIPPOCAMPAL GYRUS. This procedure is generally used for the treatment of intractable temporal epilepsy (EPILEPSY, TEMPORAL LOBE).
A composite area of the cerebral cortex concerned with motor control and sensory perception comprising the motor cortex areas, the somatosensory areas, the gustatory cortex, the olfactory areas, the auditory cortex, and the visual cortex.
Epilepsy is defined as a disorder of brain function characterized by recurrent seizures that have a sudden onset. (Oxford Medical Dictionary). A seizure is caused by a sudden burst of excess electrical activity in the brain, causing a tempora...
Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...