Prostaglandin D synthase and its functional association with immune and reproductive processes in a lepidopteran insect, Spodoptera exigua.

07:00 EST 30th November 2019 | BioPortfolio

Summary of "Prostaglandin D synthase and its functional association with immune and reproductive processes in a lepidopteran insect, Spodoptera exigua."

Several prostaglandins (PGs) have been identified in different insect species. However, their biosynthesis and physiological roles in insects remain unclear. PGD is synthesized by isomerization from PGH in mammals. This study identified a PGD synthase (SePGDS) in a lepidopteran insect, Spodoptera exigua. It showed sequence homology (32.8%) with human PGDS. Based on its conserved active site residues, its N-terminal tyrosine (Y8) was predicted to mediate electron relay from glutathione to PGH substrate, which was distinct from the catalysis of PGE (= PGD isomer) synthase (SePGES). SePGDS was highly expressed in larval and adult stages. RNA interference (RNAi) of SePGDS expression resulted in immunosuppression of cellular immune responses by suppressing the expression of actin polymerization-associated genes. It also suppressed the expression of some antimicrobial genes. Such immunosuppression induced by RNAi treatment was specifically rescued by the addition of PGD, but not its precursor, arachidonic acid. Such RNAi treatment in adults prevented egg development in females by inhibiting choriogenesis. RNAi treatment also suppressed nurse cell dumping to growing oocytes. However, the addition of PGD rescued egg development of RNAi-treated females. These results suggest that SePGDS is responsible for the production of PGD which mediates immune and reproductive processes of S. exigua.


Journal Details

This article was published in the following journal.

Name: General and comparative endocrinology
ISSN: 1095-6840
Pages: 113352


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