Balancing Act: Cell Polarity and Shape Compete to Ensure Robust Development.

07:00 EST 2nd December 2019 | BioPortfolio

Summary of "Balancing Act: Cell Polarity and Shape Compete to Ensure Robust Development."

In this issue of Developmental Cell, Niwayama et al. (2019) describe a model in which cell polarity and cell shape compete to determine the orientation of cell division in the pre-implantation mouse embryo. This model explains how simple cell-intrinsic rules lead to robust tissue-level morphogenesis and lineage segregation.


Journal Details

This article was published in the following journal.

Name: Developmental cell
ISSN: 1878-1551
Pages: 545-547


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Medical and Biotech [MESH] Definitions

A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.

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The quality of surface form or outline of the CELL NUCLEUS.

Conceptual system developed by Freud and his followers in which unconscious motivations are considered to shape normal and abnormal personality development and behavior.

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