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Balancing Act: Cell Polarity and Shape Compete to Ensure Robust Development.

07:00 EST 2nd December 2019 | BioPortfolio

Summary of "Balancing Act: Cell Polarity and Shape Compete to Ensure Robust Development."

In this issue of Developmental Cell, Niwayama et al. (2019) describe a model in which cell polarity and cell shape compete to determine the orientation of cell division in the pre-implantation mouse embryo. This model explains how simple cell-intrinsic rules lead to robust tissue-level morphogenesis and lineage segregation.

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This article was published in the following journal.

Name: Developmental cell
ISSN: 1878-1551
Pages: 545-547

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Medical and Biotech [MESH] Definitions

A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.

Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains.

The quality of surface form or outline of the CELL NUCLEUS.

Conceptual system developed by Freud and his followers in which unconscious motivations are considered to shape normal and abnormal personality development and behavior.

Regulatory signaling systems that control the progression through the CELL CYCLE. They ensure that the cell has completed, in the correct order and without mistakes, all the processes required to replicate the GENOME and CYTOPLASM, and divide them equally between two daughter cells. If cells sense they have not completed these processes or that the environment does not have the nutrients and growth hormones in place to proceed, then the cells are restrained (or "arrested") until the processes are completed and growth conditions are suitable.

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