Molecular Characterization of Hamster-Adapted Yellow Fever Virus.
Summary of "Molecular Characterization of Hamster-Adapted Yellow Fever Virus."
We previously reported two hamster models for viscerotropic yellow fever virus (YFV) infection: one using a YFV strain (Jiménez), isolated from a fatal human case in Panama in 1974, and the other using the prototype YFV strain (Asibi). Asibi hamster passage 7 (P7) was associated with accumulation of seven amino acid substitutions, including five in the envelope protein. In this study we report the genome sequences of the hamster Jiménez P0 and P10 viruses in which we identified only two amino acid substitutions during passage, one each in the nonstructural proteins NS3 and NS5, indicating a role for the nonstructural proteins in increased YFV viscerotropism in the Jiménez hamster model. Thus, there are multiple molecular mechanisms involved in viscerotropism of YFV in the hamster model. Neither Asibi P7 nor Jiménez P10 viruses were viscerotropic in mice or guinea pigs. Thus, the hamster viscerotropic phenotype did not translate to other laboratory rodent species.
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Journal Details
This article was published in the following journal.
Name: Vector borne and zoonotic diseases (Larchmont, N.Y.)
ISSN: 1557-7759
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/31794691
- DOI: http://dx.doi.org/10.1089/vbz.2019.2495
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Medical and Biotech [MESH] Definitions
Yellow Fever Vaccine
Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.
Yellow Fever Virus
The type species of the FLAVIVIRUS genus. Principal vector transmission to humans is by AEDES spp. mosquitoes.
Yellow Fever
An acute infectious disease primarily of the tropics, caused by a virus and transmitted to man by mosquitoes of the genera Aedes and Haemagogus.
Sandfly Fever Naples Virus
A species in the genus PHLEBOVIRUS causing PHLEBOTOMUS FEVER, an influenza-like illness. Related serotypes include Toscana virus and Tehran virus.
Sequivirus
A genus of plant viruses in the family SEQUIVIRIDAE. Transmission is by APHIDS but depends on the presence of a helper protein encoded by the Anthriscus yellow virus, a WAIKAVIRUS. The type species is Parsnip yellow fleck virus (parsnip serotype).
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