Photosensitized intermolecular carboimination of alkenes through persistent radical effect.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "Photosensitized intermolecular carboimination of alkenes through persistent radical effect."

An intermolecular, two-component vicinal carboimination of alkenes has been accomplished via energy transfer catalysis. Oxime esters of alkyl carboxylic acids are used as bifunctional reagents to generate both alkyl and iminyl radicals. Subsequently, the addition of alkyl radical to alkenes generates a transient radical for selective radical-radical cross coupling with persistent iminyl radical. Furthermore, this protocol readily allows for direct access to aliphatic primary amines and α -amino acids through simple hydrolysis.


Journal Details

This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773


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Medical and Biotech [MESH] Definitions

The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

Alkenes with the general formula H2C=CH-CH2-R.

Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.

Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)

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