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An intermolecular, two-component vicinal carboimination of alkenes has been accomplished via energy transfer catalysis. Oxime esters of alkyl carboxylic acids are used as bifunctional reagents to generate both alkyl and iminyl radicals. Subsequently, the addition of alkyl radical to alkenes generates a transient radical for selective radical-radical cross coupling with persistent iminyl radical. Furthermore, this protocol readily allows for direct access to aliphatic primary amines and α -amino acids through simple hydrolysis.
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
An NH4I-promoted and H2O-controlled intermolecular difunctionalization of alkenes for the synthesis of bis-methylsulfane and β-hydroxysulfides is presented. Mechanistic investigation revealed the rea...
A diverse collection of copper-catalyzed intermolecular aminative difunctionalizations of unactivated alkenes with N-halodialkylamines as the terminal dialkylamino source is reported. A bidentate auxi...
A method for the catalytic, enantioselective, intermolecular, 1,2-sulfenoamination of alkenes is described. Functionalization is achieved through the intermediacy of an enantioenriched, configurationa...
Radical-radical couplings are mostly nearly diffusion controlled processes. Therefore, the selective cross-coupling of two different radicals is challenging and not a synthetically valuable process. H...
A photoinduced, copper-catalyzed three-component radical cross-coupling of cycloketone oxime esters, alkenes, and terminal alkynes is described for the first time. Key to the success of this process w...
This study evaluates the effect of dexamethasone on persistent surgical pain after mastectomy operations. Half of the participants will receive 0.1 mg/kg dexamethasone and the other half w...
Prospective controlled study (Canadian Task Force II-2) : Comparison analysis regarding surgical outcomes, complications, overall survival (OS), disease free survival (DFS) and cancer spec...
We investigate the association between Triglyserid-Glucose(TyG) index and prostate cancer in patients undergoing radical prostatectomy.
The goal of this pilot study is to explore the efficacy of chloroquine in terminating persistent and longstanding persistent AF and assess its potential role as a pharmacological cardiover...
Acute kidney injury and chronic kidney disease usually associated with radical cystectomy operation which is the treatment of choice for invasive urinary bladders tumor. Peri-operative acu...
The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
Alkenes with the general formula H2C=CH-CH2-R.
Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.
Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)