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Patients with unresectable or non-ablatable tumors are difficult to cure, but nanotherapy combining targeted nanoparticles has many severe side effects due to toxicities of anticancer drugs. We found that acoustic energy can produce a local region with high-concentration from a low-concentration suspended liquid of nano-SiO2 particles at 2.5 MHz. Our calculated results show that the main reason of aggregation is the synthesized effect of the potential well of acoustic energy and streaming to trap them. In addition, the aggregated region can be manipulated to a targeted position in the vessel phantom by moving the ultrasound transducer external to the body. This noninvasive manipulation of suspended nanoparticles can rapidly increase the local drug concentration but reduce the total dosage of anticancer drugs, which has the potential to be used for patients with advanced tumors by improving the physiologic effects and reducing side effects.
This article was published in the following journal.
Name: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
The aggregation of nanoparticle colloidal dispersions in complex biological environments changes the nanoparticle properties, such as size and surface area, thus affecting the interaction of nanoparti...
Ultrasonic soldering utilizes high-intensity acoustic fields to induce cavitation in the solder melt in order to (i) bond dissimilar materials and (ii) improve solder joint strength. The acoustic ener...
Many commercially and industrially important materials aggregate to form nanoscale mass-fractal structures. Unlike hard aggregates such as fumed silica, aqueous pigment-based inks consist of weakly bo...
Ultrasound-triggered microbubble-assisted drug delivery is a promising tool for localized therapy. Several studies have shown the potential of nanoparticle-loaded microbubbles to effectively enhance t...
Aggregation of particles on a liquid interface is controlled by inter-particle forces and hydrodynamic interactions. Previous experimental work has shown atypical structures despite diffusion limited ...
The acoustic neuromodulation trial (ANM-T) is a two-phase, single-site, pilot randomized clinical trial examining the feasibility of completing a larger scale efficacy study of a novel tre...
Patients with acoustic neuroma had several treatment options. One of standard treatment is to receive the Gamma knife stereotactic radiosurgery, other options included suboccipital craniot...
RATIONALE: Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiati...
This pilot phase II trial studies how well nanoparticle albumin-bound rapamycin works in treating patients with cancer that as has spread to other places in the body and usually cannot be ...
Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Followed by Radiation Therapy and Erlotinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery
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Techniques using energy such as radio frequency, infrared light, laser light, visible light, or acoustic energy to transfer information without the use of wires, over both short and long distances.
Quanta of acoustic energy which move at the speed of sound.
A nonsurgical treatment that uses either HIGH-ENERGY SHOCK WAVES or low energy ACOUSTIC WAVES to treat various musculoskeletal conditions (e.g., PLANTAR FASCIITIS; TENNIS ELBOW). A probe placed on the skin conducts the shock waves thereby delivering a mechanical force to the body’s tissues.
Electric power supply devices which convert biological energy, such as chemical energy of metabolism or mechanical energy of periodic movements, into electrical energy.
The formation of clumps of RED BLOOD CELLS under low or non-flow conditions, resulting from the attraction forces between the red blood cells. The cells adhere to each other in rouleaux aggregates. Slight mechanical force, such as occurs in the circulation, is enough to disperse these aggregates. Stronger or weaker than normal aggregation may result from a variety of effects in the ERYTHROCYTE MEMBRANE or in BLOOD PLASMA. The degree of aggregation is affected by ERYTHROCYTE DEFORMABILITY, erythrocyte membrane sialylation, masking of negative surface charge by plasma proteins, etc. BLOOD VISCOSITY and the ERYTHROCYTE SEDIMENTATION RATE are affected by the amount of erythrocyte aggregation and are parameters used to measure the aggregation.
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...