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Acoustic Energy Controlled Nanoparticle Aggregation for Nanotherapy.

07:00 EST 26th November 2019 | BioPortfolio

Summary of "Acoustic Energy Controlled Nanoparticle Aggregation for Nanotherapy."

Patients with unresectable or non-ablatable tumors are difficult to cure, but nanotherapy combining targeted nanoparticles has many severe side effects due to toxicities of anticancer drugs. We found that acoustic energy can produce a local region with high-concentration from a low-concentration suspended liquid of nano-SiO2 particles at 2.5 MHz. Our calculated results show that the main reason of aggregation is the synthesized effect of the potential well of acoustic energy and streaming to trap them. In addition, the aggregated region can be manipulated to a targeted position in the vessel phantom by moving the ultrasound transducer external to the body. This noninvasive manipulation of suspended nanoparticles can rapidly increase the local drug concentration but reduce the total dosage of anticancer drugs, which has the potential to be used for patients with advanced tumors by improving the physiologic effects and reducing side effects.

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This article was published in the following journal.

Name: IEEE transactions on ultrasonics, ferroelectrics, and frequency control
ISSN: 1525-8955
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