Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models."

: After administration, a drug undergoes absorption, distribution, metabolism, and elimination (ADME) before exerting its effect on the body. The combination of these process yields the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of a drug. Although accurate prediction of PK and PD profiles are essential for drug development, conventional in vitro models are limited by their lack of physiological relevance. Recently, microtechnology-based in vitro model systems, termed "organ-on-a-chip," have emerged as a potential solution.: Orally administered drugs are absorbed through the intestinal wall and transported to the liver before entering systemic circulation, which plays important role in the PK and PD profiles. Recently developed, chip-based in vitro models can be useful models for simulating such processes and will be covered in this paper.: The potential of intestine-on-a-chip models combined with conventional PK-PD modeling has been demonstrated with promising preliminary results. However, there are several challenges to overcome. Development of the intestinal wall, integration of the gut microbiome, and the provision of an intestine-specific environment must be achieved to realize in vivo-like intestinal model and enhance the efficiency of drug development.


Journal Details

This article was published in the following journal.

Name: Expert opinion on drug metabolism & toxicology
ISSN: 1744-7607


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