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Genetic Screens to Analyze Pattern Formation of Egg and Embryo in : A Personal History.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "Genetic Screens to Analyze Pattern Formation of Egg and Embryo in : A Personal History."

In development, the axes of the egg and future embryo are established during oogenesis. To learn about the underlying genetic and molecular pathways that lead to axis formation, I conducted a large-scale genetic screen at the beginning of my independent career. This led to the eventual understanding that both anterior-posterior and dorsal-ventral pattern information is transmitted from the oocyte to the surrounding follicle cells and in turn from the follicle cells back to the oocyte. How I came to conduct this screen and what further insights were gained by studying the mutants isolated in the screen are the topics of this autobiographical article.

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This article was published in the following journal.

Name: Annual review of genetics
ISSN: 1545-2948
Pages: 1-18

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