Genetic Screens to Analyze Pattern Formation of Egg and Embryo in : A Personal History.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "Genetic Screens to Analyze Pattern Formation of Egg and Embryo in : A Personal History."

In development, the axes of the egg and future embryo are established during oogenesis. To learn about the underlying genetic and molecular pathways that lead to axis formation, I conducted a large-scale genetic screen at the beginning of my independent career. This led to the eventual understanding that both anterior-posterior and dorsal-ventral pattern information is transmitted from the oocyte to the surrounding follicle cells and in turn from the follicle cells back to the oocyte. How I came to conduct this screen and what further insights were gained by studying the mutants isolated in the screen are the topics of this autobiographical article.


Journal Details

This article was published in the following journal.

Name: Annual review of genetics
ISSN: 1545-2948
Pages: 1-18


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