07:00 EST 3rd December 2019 | BioPortfolio


Sexual dimorphism in mitochondrial respiratory function has been reported in young females and males without diabetes, which may have important implications for exercise. The purpose of this study was to determine if sexual dimorphism exists in skeletal muscle mitochondrial bioenergetics in people with type 1 diabetes (T1D). A resting muscle microbiopsy was obtained from females and males with T1D (=10/8, respectively) and without T1D (control; =8/7, respectively). High-resolution respirometry and spectrofluorometry were used to measure mitochondrial respiratory function, hydrogen peroxide (mHO) emission and calcium retention capacity (mCRC) in permeabilized myofiber bundles. The impact of T1D on mitochondrial bioenergetics between sexes was interrogated by comparing the change between females and males with T1D relative to the average values of their respective sex-matched controls (i.e. delta). These aforementioned analyses revealed that males with T1D have increased skeletal muscle mitochondrial complex I sensitivity but reduced complex II sensitivity and capacity in comparison to females with T1D. On the other hand, mHOemission was lower in females compared to males with T1D at the level of complex I (succinate-driven), while mCRC and mitochondrial protein content remained similar between sexes. In conclusion,females and males with T1D exhibit differential responses in skeletal muscle mitochondrial bioenergetics. While larger cohort studies are certainly required, these early findings nonetheless highlight the importance of considering sex as a variable in the care and treatment of people with T1D (e.g. benefits of different exercise prescriptions).


Journal Details

This article was published in the following journal.

Name: American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555


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