Genome-wide association study provides insights into the genetic architecture of bone size and mass in chickens.
Summary of "Genome-wide association study provides insights into the genetic architecture of bone size and mass in chickens."
Bone size is an important trait for chickens due to its association with osteoporosis in layers and meat production in broilers. Here, we employed high density genotyping platforms to detect candidate genes for bone traits. Estimates of the narrow heritabilities ranged from 0.37 ± 0.04 for shank length to 0.59 ± 0.04 for tibia length. The dominance heritability was 0.12±0.04 for shank length. Using a linear mixed model approach, we identified a promising locus within NCAPG on chromosome 4, which was associated with tibia length and mass, femur length and area and shank length. In addition, three other loci were associated with bone size or mass at a Bonferroni-corrected genome-wide significance threshold of 1%. One region on chicken chromosome 1 between 168.38 and 171.82 Mb, harboredHTR2A, LPAR6, CAB39L, and TRPC4. A second region that accounted for 2.2% of the phenotypic variance was located around WNT9A on chromosome 2, where allele substitution was predicted to be associated with tibia length. Four candidate genes identified on chromosome 27 comprising SPOP, NGFR, GIP, and HOXB3 were associated with tibia length and mass, femur length and area, and shank length. Genome partitioning analysis indicated that the variance explained by each chromosome was proportional to its length.
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Journal Details
This article was published in the following journal.
Name: Genome
ISSN: 1480-3321
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Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/31794256
- DOI: http://dx.doi.org/10.1139/gen-2019-0022
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Medical and Biotech [MESH] Definitions
Genome-wide Association Study
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
Transformation, Genetic
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
Microorganisms, Genetically-modified
Microorganisms whose GENOME has been altered by GENETIC ENGINEERING.
Organisms, Genetically Modified
Organisms whose GENOME has been changed by a GENETIC ENGINEERING technique.
Plants, Genetically Modified
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
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