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Owing to the favorable physical and biological properties of swift ions in matter, their application to radiation therapy for highly selective cancer treatment is rapidly spreading worldwide. To date over 90 ion therapy facilities are operational, predominantly with proton beams, and about the same amount is under construction or planning.Over the last decades considerable developments have been achieved in accelerator technology, beam delivery and medical physics to enhance conformation of the dose delivery to complex shaped tumour volumes, with excellent sparing of surrounding normal tissue and critical organs. Nevertheless, full clinical exploitation of the ion beam advantages is still challenged, especially by uncertainties in the knowledge of the beam range in the actual patient anatomy during the fractionated course of treatment, thus calling for continued multidisciplinary research in this rapidly emerging field.This contribution will review latest developments aiming to image the patient with the same beam quality as for therapy prior to treatment, and to visualize the treatment delivery by exploiting irradiation induced physical emissions, with different level of maturity from proof-of-concept studies in phantoms and first studies up to clinical testing and initial clinical evaluation.
This article was published in the following journal.
Name: The British journal of radiology
In this article, an overview of the current developments and research applications for non-proton magnetic resonance imaging (MRI) at ultrahigh magnetic fields (UHFs) is given. Due to technical and me...
To evaluate the incidence of imaging changes in our pediatric brain tumor population treated with spot scanning proton therapy, and analyze the spatial correlation of imaging changes with a novel biol...
Proton therapy is currently used in the management of pediatric tumors to decrease late toxicities. However, one of the criticisms of proton therapy is the limited data regarding efficacy on disease c...
In vivo range verification in proton therapy is a critical step to help minimize range and dose uncertainty. We propose to employ a time reversal (TR)-based approach using proton-induced acoustics (pr...
Treatment planning for proton therapy requires the relative proton stopping power ratio (RSP) information of the patient for accurate dose calculations. RSP are conventionally obtained after mapping o...
Primary Objectives: To establish the efficacy of proton beam therapy with or without photon beam radiation therapy for skull base chordoma. Secondary Objectives: 1. To det...
The purpose of this research study is to compare the effects (good and bad) on subjects and their cancer using proton radiation therapy in combination with immunotherapy(ie. Programmed cel...
This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes [quality of life (QOL), toxicity, and disease control] between parallel cohorts of men with...
The purpose of this study is to see what effects, good and/or bad, image guided proton based radiation combined with low dose chemotherapy and hormonal therapy has on you and your cancer.
The purpose of this research study is to determine whether the amount of radiation given to the normal areas around the anal cancer can be reduced by using Proton Therapy while reducing th...
The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.
Non-invasive imaging of cells that have been labeled non-destructively, such as with nanoemulsions or reporter genes that can be detected by molecular imaging, to monitor their location, viability, cell lineage expansion, response to drugs, movement, or other behaviors in vivo.
The use of an external beam of PROTONS as radiotherapy.
A complex of enzymes and PROTON PUMPS located on the inner membrane of the MITOCHONDRIA and in bacterial membranes. The protein complex provides energy in the form of an electrochemical gradient, which may be used by either MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES or BACTERIAL PROTON-TRANSLOCATING ATPASES.
The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...
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