Metal-Free Synthesis of 3-(Iso)quinolinyl 4-Chromenones and 3-(Iso)quinolinyl 4-Quinolones from (Iso)quinoline -Oxides and Ynones.

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Summary of "Metal-Free Synthesis of 3-(Iso)quinolinyl 4-Chromenones and 3-(Iso)quinolinyl 4-Quinolones from (Iso)quinoline -Oxides and Ynones."

A general approach for the synthesis of 3-(iso)quinolinyl 4-chromenones and 3-(iso)quinolinyl 4-quinolones from (iso)quinoline -oxides and ynones under metal-free conditions was developed. The reaction of (iso)quinoline -oxide with the electron-deficient alkyne first generated an (iso)quinolinyl β-diketone intermediate, which then underwent an intramolecular dehydration, affording 3-(iso)quinolinyl 4-chromenones and 3-(iso)quinolinyl 4-quinolones.


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Name: Organic letters
ISSN: 1523-7052


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