Protein-Sugar-Glass Nanoparticle Platform for the Development of Sustained-Release Protein Depots by Overcoming Protein Delivery Challenges.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "Protein-Sugar-Glass Nanoparticle Platform for the Development of Sustained-Release Protein Depots by Overcoming Protein Delivery Challenges."

Therapeutic protein depots have limited clinical success because of the presence of critical preparation barriers such as low encapsulation, uncontrolled release, and activity loss during processing and storage. In the present study, we used our novel protein-nanoencapsulation (into sugar-glass nanoparticle; SGnP) platform to prepare a protein depot to overcome the abovementioned formidable challenges. The SGnP-mediated microparticle protein depot has been validated using four model proteins (bovine serum albumin, horseradish peroxidase, fibroblastic growth factor, and epidermal growth factor) and model biodegradable poly(lactic--glycolic acid) polymer system. The results show that our protein-nanoencapsulation-mediated platform provides a new generic platform to prepare a protein depot through the conventional emulsion method of any polymer and single/multiple protein systems. This protein depot has the required pharmaceutical properties such as high encapsulation efficiency, burst-free sustained release, and protein preservation during processing and storage, making it suitable for off-the-shelf use in therapeutic protein delivery and tissue engineering applications.


Journal Details

This article was published in the following journal.

Name: Molecular pharmaceutics
ISSN: 1543-8392


DeepDyve research library

PubMed Articles [25040 Associated PubMed Articles listed on BioPortfolio]

Sustained Release of Silibinin loaded in Chitosan Nanoparticle Induced Apoptosis in Glioma Cells.

In this study, a chitosan nanoparticle formulation was synthesized for loading silibinin as a sustained release drug system to evaluate its effects on apoptosis in C6 glioma cells. This synthesized na...

Media interaction and stability of a gamma irradiated albumin nanoparticle.

Protein nanoparticle designing at the nanoscale is challenging because of protein vulnerability to chemical and physical degradation during processing and biodistribution. We present a crosslinked gam...

Engineering Biocoatings To Prolong Drug Release from Supraparticles.

Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of interest for long-term, sustained drug release in biomedical applications. H...

Self-Assembled Micelles Based on Gambogenic acid-Phospholipid Complex for Sustained-Release Drug Delivery.

To improve the water solubility and enhance the oral bioavailability of GNA(Gambogenic acid). GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. The encap...

Oxidized konjac glucomannan-cassava starch and sucrose esters as novel excipients for sustained-release matrix tablets.

A novel sustained-release matrix tablet was developed through wet granulation by using oxidized konjac glucomannan-cassava starch (OKGM-CS) and sucrose esters (SE) as excipients. OKGM-CS treated by dr...

Clinical Trials [9639 Associated Clinical Trials listed on BioPortfolio]

Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) Vs Placebo in Peri- and Postmenopausal Women

Desvenlafaxine succinate (DVS) is a potent and selective serotonin and norepinephrine reuptake inhibitor (SNRI). The sustained-release (SR) formulation, DVS SR, is being studied in the de...

A Relative Bioavailability Study of Bupropion Sustained Release 150 mg Tablets Under Fasting Conditions

The purpose of this study is to compare the rate and extent of absorption of Abrika Bupropion 150 mg sustained release tablet to that of Wellbutrin SR sustained release tablet after a sing...

Feasibility Study Evaluating Safety and Efficacy of OTX-DP (Sustained Release Dexamethasone, 0.4mg) for Treatment of Dry Eye

To evaluate the safety and efficacy of OTX-DP as a sustained release drug (dexamethasone, 0.4mg) depot when placed in the canaliculus of the eyelid in subjects who exhibit signs and sympto...

Safety and Pharmacokinetics of Sustained-release Depot Tacrolimus: A First-in-human Study

This first-in-human study is designed to assess the safety and pharmacokinetic (PK) profile of sustained-release (SR) depot tacrolimus, which will be administered as a single dose of 0.1 m...

CLONICEL (Clonidine Sustained Release) as Add-on to Stimulant Medication in 6 to 17 Yr-olds With ADHD

The purpose of this study is to determine if CLONICEL (clonidine HCl sustained release) is a safe and effective add-on to psychostimulant therapy in children and adolescents with attention...

Medical and Biotech [MESH] Definitions

Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.

A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C.

Composite materials composed of an ion-leachable glass embedded in a polymeric matrix. They differ from GLASS IONOMER CEMENTS in that partially silanized glass particles are used to provide a direct bond to the resin matrix and the matrix is primarily formed by a light-activated, radical polymerization reaction.

A framework for development and promotion of common data formats and exchange protocols linked in a way that can be read directly by computers. Semantic Web is a platform for sharing and reusing data across application, enterprise, and community boundaries, by linking concepts rather than just documents.

Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.

Quick Search

DeepDyve research library

Relevant Topics

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Gene Therapy
Gene therapy is the use of DNA as a pharmaceutical agent to treat disease. It derives its name from the idea that DNA can be used to supplement or alter genes within an individual's cells as a therapy to treat disease. The most common form of gene th...

Searches Linking to this Article