Integrating MS-based metabolomics approaches, LC-MS-PCA and molecular networking enabled the targeted isolation of five new pyrrole-derived alkaloids, phallusialides A-E (-), from a marine-derived sp. bacterium. The structures of - were elucidated by analysis of their HRMS, MS/MS, and NMR spectroscopic data. The absolute configuration of phallusialide A () was determined on the basis of comparisons of experimental and theoretically calculated ECD spectra. Compounds and exhibited antibacterial activity against methicillin resistant (MRSA) and , with MIC values of 32 and 64 μg/mL, respectively, whereas - showed no antibacterial activity even at 256 μg/mL, yielding important SAR insights for this class of compounds.
This article was published in the following journal.
Name: Journal of natural products
ISSN: 1520-6025
Pages:
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Indole Alkaloids
Group of alkaloids containing a benzylpyrrole group (derived from TRYPTOPHAN)
Amaryllidaceae Alkaloids
Alkaloids derived from TYRAMINE combined with 3,4-dihydroxybenzaldehyde via a norbelladine pathway, including GALANTAMINE, lycorine and crinine. They are found in the Amaryllidaceae (LILIACEAE) plant family.
Cloning, Organism
The formation of one or more genetically identical organisms derived by vegetative reproduction from a single cell. The source nuclear material can be embryo-derived, fetus-derived, or taken from an adult somatic cell.
Cat's Claw
A vine (Uncaria tomentosa) indigenous to the Amazon rainforest whose name is derived from its hook-like thorns. It contains oxindole alkaloids and glycosides and has many medicinal uses.
Rauwolfia
A plant genus of the APOCYNACEAE or dogbane family. Alkaloids from plants in this genus have been used as tranquilizers and antihypertensive agents. RESERPINE is derived from R. serpentina.
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