A novel Ce(Ⅲ)-MOF with luminescent property to fabricate an electrochemiluminescence immunosensor.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "A novel Ce(Ⅲ)-MOF with luminescent property to fabricate an electrochemiluminescence immunosensor."

We designed a novel luminescent metal-organic framework (LMOF) named CTM through a simple one-pot solvothermal method. CTM was synthesized by using the emerging electrochemiluminescent (ECL) material (4,4',4'',4'''-(porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid) as organic ligand and Ce(Ⅲ) as metal node. We found that CTM not only has the remarkable ability to emit light but also has a uniform "sandwich biscuit" shape and suitable nanoscale size, which are promising for further applications. We also applied CTM to construct a novel ECL immunosensor and achieve the sensitive detection of the proprotein convertase subtilisin/kexin type 9 (PCSK9), a biomarker related to cardiovascular diseases (CVDs). To further amplify the ECL signal of CTM, a novel dual-amplified signal strategy was established by inducing polyamidoamine dendrimer (PAMAM) and gold nanoparticle (AuNPs). Importantly, we firstly proved that the ECL signal of CTM/S2O82- system could be enhanced by PAMAM electric field. Since the electron transfer rate was accelerated by AuNPs layer, this ECL signal was further enhanced in AuNPs-modified electrodes. The ECL immunosensor showed desirable performance for PCSK9 analysis within a detection range of 50 fg mL to 10 ng mL and a low LOD of 19.12 ± 2.69 fg mL. Real sample detection suggested that the immunosensor holds great potential for clinical serum samples analyzing.


Journal Details

This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252


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Techniques using light resulting from PHYSICAL LUMINESCENCE emitted by LUMINESCENT PROTEINS and LUMINESCENT AGENTS.

Compound such as LUMINESCENT PROTEINS that cause or emit light (PHYSICAL LUMINESCENCE).


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