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A novel Ce(Ⅲ)-MOF with luminescent property to fabricate an electrochemiluminescence immunosensor.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "A novel Ce(Ⅲ)-MOF with luminescent property to fabricate an electrochemiluminescence immunosensor."

We designed a novel luminescent metal-organic framework (LMOF) named CTM through a simple one-pot solvothermal method. CTM was synthesized by using the emerging electrochemiluminescent (ECL) material (4,4',4'',4'''-(porphine-5,10,15,20-tetrayl)tetrakis(benzoic acid) as organic ligand and Ce(Ⅲ) as metal node. We found that CTM not only has the remarkable ability to emit light but also has a uniform "sandwich biscuit" shape and suitable nanoscale size, which are promising for further applications. We also applied CTM to construct a novel ECL immunosensor and achieve the sensitive detection of the proprotein convertase subtilisin/kexin type 9 (PCSK9), a biomarker related to cardiovascular diseases (CVDs). To further amplify the ECL signal of CTM, a novel dual-amplified signal strategy was established by inducing polyamidoamine dendrimer (PAMAM) and gold nanoparticle (AuNPs). Importantly, we firstly proved that the ECL signal of CTM/S2O82- system could be enhanced by PAMAM electric field. Since the electron transfer rate was accelerated by AuNPs layer, this ECL signal was further enhanced in AuNPs-modified electrodes. The ECL immunosensor showed desirable performance for PCSK9 analysis within a detection range of 50 fg mL to 10 ng mL and a low LOD of 19.12 ± 2.69 fg mL. Real sample detection suggested that the immunosensor holds great potential for clinical serum samples analyzing.

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This article was published in the following journal.

Name: ACS applied materials & interfaces
ISSN: 1944-8252
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Medical and Biotech [MESH] Definitions

Techniques using light resulting from PHYSICAL LUMINESCENCE emitted by LUMINESCENT PROTEINS and LUMINESCENT AGENTS.

Compound such as LUMINESCENT PROTEINS that cause or emit light (PHYSICAL LUMINESCENCE).

Measurement of light resulting from PHYSICAL CHEMILUMINESCENCE such as from LUMINESCENT PROTEINS and LUMINESCENT AGENTS.

Emission of LIGHT when ELECTRONS return to the electronic ground state from an excited state and lose the energy as PHOTONS. It is sometimes called cool light in contrast to INCANDESCENCE. LUMINESCENT MEASUREMENTS take advantage of this type of light emitted from LUMINESCENT AGENTS.

The mechanical property of material that determines its resistance to force. HARDNESS TESTS measure this property.

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