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Chiral covalent organic frameworks (CCOFs), built by the condensation reactions of organic building blocks with enantiomeric purity and linking subunits, have emerged as a marvelous category of porous crystalline material. In addition to stability and good porosity, CCOFs possess remarkable enantioselectivity, which would be exploited for asymmetric catalysis and chiral separation. β-cyclodextrin (β-CD) and its derivatives, a group of supramolecules with a hydrophobic cavity, have been widely applied to molecular specific recognitions. In this work, β-CD COF was exploited to construct chiral stationary phase (CSP) for chiral drugs analysis for the first time. We fabricated β-CD COF by the condensation reaction of heptakis(6-amino-6-deoxy)-β-CD and terephthalaldehyde at room temperature. β-CD COF modified capillary columns were subsequently prepared by a photo-polymerization method with shortened time and applied for separation of chiral drugs on capillary electrochromatography with good resolution and repeatability. Baseline separation for six enantiomers was achieved and the precisions (relative standard deviations) for intra-day, inter-day and column-to-column were less than 2.1%, 4.5% and 7.3%, respectively. The results reveal that CCOFs coated capillary columns show great prospect for chromatographic separation of chiral drugs.
This article was published in the following journal.
Name: ACS applied materials & interfaces
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Derivative of beta-cyclodextrin that is used as an excipient for steroid drugs and as a lipid chelator.
Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.
Funding resources and procedures for capital improvement or the construction of facilities.
Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).
Architecture, exterior and interior design, and construction of facilities other than hospitals, e.g., dental schools, medical schools, ambulatory care clinics, and specified units of health care facilities. The concept also includes architecture, design, and construction of specialized contained, controlled, or closed research environments including those of space labs and stations.