Recurrence of Serotonin Toxicity and Influence of Cytochrome 2D6 Polymorphism.

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Summary of "Recurrence of Serotonin Toxicity and Influence of Cytochrome 2D6 Polymorphism."

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Name: The primary care companion for CNS disorders
ISSN: 2155-7780


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Medical and Biotech [MESH] Definitions

Cell-surface proteins that bind SEROTONIN and trigger intracellular changes which influence the behavior of cells. Several types of serotonin receptors have been recognized which differ in their pharmacology, molecular biology, and mode of action.

Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonin agonists.

Drugs that bind to but do not activate SEROTONIN 5-HT4 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN RECEPTOR AGONISTS.

Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.

An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.

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