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Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins."

Asymmetric hydrogenation has evolved as one of the most powerful tools to construct stereocenters. However, the asymmetric hydrogenation of unfunctionalized, tetrasubstituted, acyclic olefins remains the pinnacle of asymmetric synthesis and an unsolved challenge. We report herein the discovery of an iridium catalyst for the first, generally-applicable, highly enantio- and diastereoselective hydrogenation of such olefins and the mechanistic insights of the reaction. The power of this chemistry is demonstrated by the successful hydrogenation of a wide variety of electronically and sterically diverse olefins in excellent yield, enantio- and diastereoselectivity.

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This article was published in the following journal.

Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
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