Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins.
Summary of "Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins."
Asymmetric hydrogenation has evolved as one of the most powerful tools to construct stereocenters. However, the asymmetric hydrogenation of unfunctionalized, tetrasubstituted, acyclic olefins remains the pinnacle of asymmetric synthesis and an unsolved challenge. We report herein the discovery of an iridium catalyst for the first, generally-applicable, highly enantio- and diastereoselective hydrogenation of such olefins and the mechanistic insights of the reaction. The power of this chemistry is demonstrated by the successful hydrogenation of a wide variety of electronically and sterically diverse olefins in excellent yield, enantio- and diastereoselectivity.
Affiliation
Journal Details
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/31794118
- DOI: http://dx.doi.org/10.1002/anie.201912640
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Medical and Biotech [MESH] Definitions
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Addition of hydrogen to a compound, especially to an unsaturated fat or fatty acid. (From Stedman, 26th ed)
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Acyclic diterpene used in making synthetic forms of vitamin E and vitamin K1.
Alkadienes
Acyclic branched or unbranched hydrocarbons having two carbon-carbon double bonds.
Dicarboxylic Acids
Acyclic acids that contain two carboxyl groups and have the formula HO2C-R-CO2H, where R may be an aromatic or aliphatic group.
Oxazocines
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