Furan Derived Chiral Bicycloaziridino Lactone Synthon: Collective Syntheses of Oseltamivir Phosphate (Tamiflu), (S)-Pipecolic acid and its 3-Hydroxy Derivatives.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "Furan Derived Chiral Bicycloaziridino Lactone Synthon: Collective Syntheses of Oseltamivir Phosphate (Tamiflu), (S)-Pipecolic acid and its 3-Hydroxy Derivatives."

The unified synthetic strategy for oseltamivir phosphate (tamiflu), ( S )-pipecolic acid and its 3-hydroxy derivatives from furan derived common chiral bicycloaziridino lactone synthon is described here. Key features are short (4-steps), enantiopure, and decagram scale synthesis of common chiral synthon from furan and its first-ever application in the total synthesis of biologically active compounds by taking the advantages of high functionalization ability of chiral synthon.


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This article was published in the following journal.

Name: Chemistry, an Asian journal
ISSN: 1861-471X


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