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The unified synthetic strategy for oseltamivir phosphate (tamiflu), ( S )-pipecolic acid and its 3-hydroxy derivatives from furan derived common chiral bicycloaziridino lactone synthon is described here. Key features are short (4-steps), enantiopure, and decagram scale synthesis of common chiral synthon from furan and its first-ever application in the total synthesis of biologically active compounds by taking the advantages of high functionalization ability of chiral synthon.
This article was published in the following journal.
Name: Chemistry, an Asian journal
The first enantioselective total syntheses of pallambins A-D have been achieved in 15 or 16 steps from known chiral cyclohexenone. Salient features of the work include a Pd-catalyzed oxidative cycliza...
Recent experiments on monolayers of spindle-like cells plated on adhesive stripe-shaped domains have provided a convincing demonstration that certain types of collective phenomena in epithelia are wel...
The conversion of biomass-based platform molecules into various high-value chemicals greatly promote the utilization of renewable biomass resources. Herein, we reported an example of Rh-catalyzed β- ...
An efficient total synthesis of the revised structure of the sensitive triyne natural product, (4,5)-4,8-dihydroxy-3,4-dihydrovernoniyne, and all of its stereoisomers, that is, the previously proposed...
The last two decades have witnessed a significant growth in using bio-derived materials, driven by the necessity of replacing fossil-derived precursors, reducing the fossil fuel consumption, and lower...
The aim of this study is to evaluate the safety and effectivity of Ginkgo diterpene lactone meglumine injection tn the treatment of acute ischemic stroke
This study evaluates the addition of Ginkgo Diterpene Lactone Meglumine Injection to aspirin in the treatment of acute ischemic stroke.Half of patient will receive Ginkgo Diterpene Lactone...
This study will advance computer tailoring by adapting machine learning collective intelligence algorithms that have been used outside healthcare by companies like Amazon and Google to enh...
The purposes of this study include: - Determination of the change in clearance of topotecan and topotecan lactone between day 1 and day 14 for patients receiving treatment with p....
Schemas describe mental structures storing recurrent and organized pattern of information. Schemas may have a strong influence on the process of storing and retrieving new information into...
Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.
Enzymes that catalyze the epimerization of chiral centers within carbohydrates or their derivatives. EC 5.1.3.
A theoretical psychoanalytical system centered around symbols of the unconscious with the unconscious material derived from two sources - the personal unconscious (repressed or forgotten experiences, thoughts and feelings) and the collective or objective unconscious (the universal inherited qualities which dispose individuals to behave in ways similar to their ancestors).
A white crystalline compound prepared by condensation of benzaldehyde in potassium cyanide and used in organic syntheses. This should not be confused with benzoin gum from STYRAX.
Enzymes that catalyze either the racemization or epimerization of chiral centers within amino acids or derivatives. EC 5.1.1.