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The ternary complex factor protein ELK1 is an independent prognosticator of disease recurrence in prostate cancer.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "The ternary complex factor protein ELK1 is an independent prognosticator of disease recurrence in prostate cancer."

Both hormone-sensitive and castration- and enzalutamide-resistant prostate cancers (PCa) depend on the ternary complex factor (TCF) protein ELK1 to serve as a tethering protein for the androgen receptor (AR) to activate a critical set of growth genes. The two sites in ELK1 required for AR binding are conserved in other members of the TCF subfamily, ELK3 and ELK4. Here we examine the potential utility of the three proteins as prognosticators of disease recurrence in PCa.

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Name: The Prostate
ISSN: 1097-0045
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Medical and Biotech [MESH] Definitions

Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.

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