ASC1 is a cell cycle regulator associated with severe and mild forms of myopathy.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "ASC1 is a cell cycle regulator associated with severe and mild forms of myopathy."

Recently, the ASC-1 complex has been identified as a mechanistic link between ALS and spinal muscular atrophy (SMA), and three mutations of the ASC-1 gene TRIP4 have been associated with SMA or congenital myopathy. Our goal was to define ASC-1 neuromuscular function and the phenotypical spectrum associated with TRIP4 mutations.


Journal Details

This article was published in the following journal.

Name: Annals of neurology
ISSN: 1531-8249


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A cyclin subtype that binds to the CYCLIN-DEPENDENT KINASE 3 and CYCLIN-DEPENDENT KINASE 8. Cyclin C plays a dual role as a transcriptional regulator and a G1 phase CELL CYCLE regulator.

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