Effects of continuous flow left ventricular assist devices on cerebral hemodynamics.

07:00 EST 3rd December 2019 | BioPortfolio

Summary of "Effects of continuous flow left ventricular assist devices on cerebral hemodynamics."

Continuous-flow left ventricular assist devices (LVADs) reduce peak systolic flow, increase diastolic flow, and eliminate pulsatility of circulation. Altered blood flow may lead to a change in end-organ perfusion. Analysis of the flow dynamics of the arteries of end-organs, such as the brain, may indicate whether an organ is perfused sufficiently. The aim of this study is to evaluate and identify the flow pattern changes of carotid (CA) and middle cerebral arteries (MCA) in LVAD patients and to compare with heart failure patients and healthy volunteers. Eighty-nine individuals were included in this cross-sectional study. Participants were divided into three groups: LVAD patients (n=31), heart failure patients (n=26), and healthy volunteers (n=27). Carotid and transcranial Doppler ultrasonography were performed for all study groups for peak systolic velocity (PSV), end-diastolic velocity (EDV), pulsatility (PI), and resistive (RI) indices of CA and MCA. Flow dynamics were compared between the groups. Doppler ultrasonographic data were analyzed median 12 (3-47) months after LVAD implantation. CA-PSV was lower in LVAD group compared with the other two groups (p<0.001), MCA-PSV of LVAD and heart failure groups were similar and lower than healthy volunteers (p<0.05). The highest values for CA-EDV were found in LVAD group (p<0.05). MCA-EDV values were found to be lowest in heart failure group (p<0.05). For PI and RI, in all CA and MCA, LVAD group had lower indices compared with the other two groups (p<0.001). In addition, MCA flow analysis in patients with LVAD was identified for the first time with this study.


Journal Details

This article was published in the following journal.

Name: Artificial organs
ISSN: 1525-1594


DeepDyve research library

PubMed Articles [24437 Associated PubMed Articles listed on BioPortfolio]

Incidence, predictors and clinical impact of electrical storm in patients with left ventricular assist devices: new insights from the ASSIST-ICD study.

Ventricular arrhythmias (VAs) can occur after continuous-flow left ventricular assist devices (LVAD) implantation, as a single arrhythmic event, or as an electrical storm (ES) with multiple repetitive...

Long-term continuous flow mechanical biventricular support: 9 years and counting.

We report 2 continuous flow HeartWareTM left ventricular assist devices successfully used in a patient with advanced heart failure of giant cell myocarditis origin in a biventricular configuration. De...

Cerebral blood flow responses to exercise are enhanced in left ventricular assist device patients following an exercise rehabilitation program.

Cerebral blood flow during exercise is impaired in heart failure patients implanted with left ventricular assist devices (LVADs). Our aim was to determine whether a 3-month exercise training program c...

Haemodynamic evaluation of the new pulsatile-flow generation method in vitro.

Continuous-flow ventricular-assist devices are widely used to support patients with advanced heart failure, because continuous-flow ventricular-assist devices are more durable, have smaller sizes and ...

Utilization of Left Ventricular Assist Devices in Vulnerable Adults Across Medicaid Expansion.

Continuous-flow left ventricular assist device (LVAD) implantation is a payor sensitive procedure influenced by preoperative comorbidities and social factors. Whether expansion in insurance coverage w...

Clinical Trials [12509 Associated Clinical Trials listed on BioPortfolio]

Determination of Risk Factors of Ventricular Arrhythmias (VAs) After Implantation of Continuous Flow Left Ventricular Assist Device With Continuous Flow Left Ventricular Assist Device (CF-LVAD)

Determination of risk factors of ventricular arrhythmias (VAs) after implantation of continuous flow left ventricular assist device in order to characterize which patient requires ICD impl...

Exercise Training in Patients With Left Ventricular Assist Device

The objective of the study is to test whether 12 weeks of structured supervised exercise training on top of usual care improves functional capacity in patients with end-stage heart failure...

Data Collection During CT for Axial Flow VADs

At present, there is not accurate way to determine specific flow rates for axial flow ventricular assist devices (VADS). If a right heart cath is needed for these patients for clinical pu...

Investigation to Optimize Hemodynamic Management of Left Ventricular Assist Devices Using the CardioMEMS™

This observational post market study is intended to characterize hemodynamic-guided management of patients with an existing left ventricular assist device (LVAD) to protocol specified targ...

Effect of Cardiac Resynchronization Therapy (CRT) on Left Ventricular Assist Device (LVAD) Function

Certain patients with congestive heart failure are treated both by implantation of an LVAD, as well as implantation with a biventricular pacemaker. Both of these devices, individually, hav...

Medical and Biotech [MESH] Definitions

Diversion of the flow of blood from the pulmonary veins directly to the aorta, avoiding the left atrium and the left ventricle (Dorland, 27th ed). This is a temporary procedure usually performed to assist other surgical procedures.

A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).

Rare congenital cardiomyopathies characterized by the lack of left ventricular myocardium compaction. The noncompaction results in numerous prominent trabeculations and a loose myocardial meshwork (spongy myocardium) in the LEFT VENTRICLE. Heterogeneous clinical features include diminished systolic function sometimes associated with left ventricular dilation, that presents either neonatally or progressively. Often, the RIGHT VENTRICLE is also affected. CONGESTIVE HEART FAILURE; PULMONARY EMBOLISM; and ventricular ARRHYTHMIA are commonly seen.

Absence of the orifice between the RIGHT ATRIUM and RIGHT VENTRICLE, with the presence of an atrial defect through which all the systemic venous return reaches the left heart. As a result, there is left ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR) because the right ventricle is absent or not functional.

A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.

Quick Search

DeepDyve research library

Searches Linking to this Article