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Effects of pharmacogenetic variants on vemurafenib-related toxicities in patients with melanoma.

07:00 EST 1st December 2019 | BioPortfolio

Summary of "Effects of pharmacogenetic variants on vemurafenib-related toxicities in patients with melanoma."

The pharmacokinetics and pharmacodynamics of vemurafenib are characterized by a wide interpatient variability. Since multiple polymorphic enzymes and drug transporters are involved in vemurafenib pharmacokinetics, we studied associations of polymorphisms on vemurafenib-associated toxicities. Prospectively collected samples of 97 melanoma patients treated with vemurafenib alone (n = 62) or in combination with cobimetinib (n = 35) were genotyped for (3435C>T), (421C>A, 34G>A) and (, 15389C>T) polymorphisms. Associations between these variants and the incidence of toxicities were studied. was significantly associated with increased risk for grade ≥3 nausea, grade 1-4 hyperbilirubinemia, and cutaneous squamous cell carcinoma. 3435C>T was a predictor for grade ≥3 toxicity. Genetic variants in and are associated with vemurafenib-associated toxicities.

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This article was published in the following journal.

Name: Pharmacogenomics
ISSN: 1744-8042
Pages: 1283-1290

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