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The pharmacokinetics of carbetocin, which is used to control postpartum hemorrhage after giving birth, was studied in cows and gilts after a single intravenous (IV) or intramuscular (IM) injection. Blood samples from animals were assessed by oxytocin radioimmunoassay, and then the pharmacokinetic parameters were calculated using a noncompartmental model. For gilts, there was no significant difference between half-life (T ), mean residue time (MRT), and maximum concentration (C ) between IM and IV administration. Conversely, the time to reach the C (T ) and MRT were higher following administration of 350 μg/animal in cows via the IM administration compared with IV. The longest T was 0.85 hr, indicating carbetocin was absorbed and eliminated rapidly in both animal species after administration. The T was similar between cows and gilts following IM administration. Moreover, the C after IM injection was about half that of IV administration in both animals. The bioavailability was more than 80% in cows, suggesting administration via the IM route is efficient. This is in agreement with the longer T in cows after IM administration. However, the IV route is recommended for gilts due to a lower bioavailability (35%) and shorter T after IM administration compared with IV.
This article was published in the following journal.
Name: Journal of veterinary pharmacology and therapeutics
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Intramuscular carbetocin is as effective as intramuscular syntometrine for the prevention of postpartum haemorrhage
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Delivery of substances through VENIPUNCTURE into the VEINS.
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
The administration of medication or fluid through a needle directly into the bone marrow. The technique is especially useful in the management of pediatric emergencies when intravenous access to the systemic circulation is difficult.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
A disease of pregnant and lactating cows and ewes leading to generalized paresis and death. The disease, which is characterized by hypocalcemia, occurs at or shortly after parturition in cows and within weeks before or after parturition in ewes.
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