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Iron Hydride Radical Reductive Alkylation of Unactivated Alkenes.

07:00 EST 30th December 2019 | BioPortfolio

Summary of "Iron Hydride Radical Reductive Alkylation of Unactivated Alkenes."

Iron-catalyzed hydrogen atom transfer-mediated intermolecular C-C coupling reactions between alkenes and tosylhydrazones, followed by in situ cleavage of the tosylhydrazine intermediates using EtN, are described. The process involves a new strategic bond disconnection resulting in the reductive alkylation of nonactivated alkenes. The reaction is operationally simple, proceeds under mild conditions, and has a wide substrate scope.

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Name: Organic letters
ISSN: 1523-7052
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