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The surfactant-free nature and higher stability of Pickering emulsions make them preferable solutions over conventional emulsions for skin applications. In this work, Pickering emulsions stabilized by chitosan/gum Arabic (CH/GA) nanoparticles were tested as vehicles for trans-resveratrol topical delivery. Skin absorption was examined ex vivo using Franz diffusion cells and porcine skin. Pickering emulsions allowed higher cutaneous retention and lower permeation of resveratrol, in comparison with a control solution based on a 20% v/v ethanol. The total amount of resveratrol retained in the skin, 24 h after the application, was 11.60% and 10.82% of the applied dose for the tested Pickering emulsion-based formulations prepared with 0.5% and 1.5% w/v CH/GA nanoparticles, respectively. In contrast, resveratrol skin retention from the control solution was only 2.86%. Confocal laser scanning microscopy revealed enhanced skin deposition of Nile Red to deeper layers from the Pickering emulsion-based formulations. Moreover, Pickering emulsions led to trans-resveratrol photostability increase, as measured after exposure to UV for 4 h. These results show that the CH/GA Pickering emulsions are promising solutions for the topical delivery of trans-resveratrol and have the potential to be used as green cosmetic products.
This article was published in the following journal.
Name: International journal of biological macromolecules
Resveratrol is a wonder therapy for the treatment of several skin disorders including psoriasis. But its skin permeation limits its applications.
In this study, cyclodextrin metal-organic framework/chitosan (CD-MOF/CS) nanocapsules, which have a hydrophobic core and a hydrophilic shell, were fabricated as delivery systems for bioactive agents. ...
Trans-resveratrol was added to 'Blaufränkisch' red wine to determine the changes in total phenolics, total anthocyanins, and antioxidant potential. The results of this first investigation were presen...
Peanut sprouts are a functional food material rich in phytochemicals, including trans-resveratrol. This study aimed to optimize the recovery of trans-resveratrol from peanut sprouts using a combinatio...
The effects of extended maceration (13 days) were investigated for extraction of trans-resveratrol and other phenolics from grapes of cultivar 'Blaufränkisch', and then during the subsequent maturati...
The purpose of the study was to investigate the effect of food on the pharmacokinetics of a single 400 mg dose of BIA 6-512 (trans-resveratrol) in healthy volunteers
This is an interventional, prospective, randomized, comparative monocentric study aiming to evaluate the safety and efficacy of Resveratrol to reduce the progression of exudative Age-Relat...
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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Hyperandrogenism is the central feature of PCOS. Studies on isolated ovarian theca-i...
To enhance the oral bioavailability of the antioxidants trans-resveratrol and trans-ε-viniferin from Vineatrol30 grapevine-shoot extract, the native powder was incorporated into micelles....
The joining of RNA from two different genes. One type of trans-splicing is the "spliced leader" type (primarily found in protozoans such as trypanosomes and in lower invertebrates such as nematodes) which results in the addition of a capped, noncoding, spliced leader sequence to the 5' end of mRNAs. Another type of trans-splicing is the "discontinuous group II introns" type (found in plant/algal chloroplasts and plant mitochondria) which results in the joining of two independently transcribed coding sequences. Both are mechanistically similar to conventional nuclear pre-mRNA cis-splicing. Mammalian cells are also capable of trans-splicing.
Fluorides, usually in pastes or gels, used for topical application to reduce the incidence of DENTAL CARIES.
A member of the P450 superfamily, this enzyme catalyzes the first oxidative step of the phenylpropanoid pathway in higher PLANTS by transforming trans-cinnamate into p-coumarate.
An enzyme that catalyzes the synthesis of geranylgeranyl diphosphate from trans, trans-farnesyl diphosphate and isopentenyl diphosphate.
Trans-acting proteins which accelerate retroviral virus replication. The vpr proteins act in trans to increase the levels of specified proteins. vpr is short for viral protein R, where R is undefined.
Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...