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Design and fabrication of electrospun SBA-15 incorporated PVA with Curcumin: a biomimetic nanoscaffold for skin tissue engineering.

07:00 EST 14th January 2020 | BioPortfolio

Summary of "Design and fabrication of electrospun SBA-15 incorporated PVA with Curcumin: a biomimetic nanoscaffold for skin tissue engineering."

Fabricating and designing a scaffold is a complex and highly challenging process in current scenario. The present study deals with the design and fabrication of electrospun SBA-15 (Santa Barbara Amorphous) incorporated PVA (Poly Vinyl Alcohol) with Curcumin which can be used as a biomimetic nanoscaffold for skin tissue engineering. Curcumin was selected due to its effectiveness in anti-microbial and anti-inflammatory properties. SBA-15 was selected for its characteristic drug carrying potential. FTIR and XRD characterizations of fabricated nanofiber expressed the interaction of PVA, SBA-15 and Curcumin. SEM results depicted that the nanofiber was highly interconnected with porous structure mimicking Extra Cellular Matrix (ECM). The nanofibrous scaffold showed higher percentage of cell migration, proliferation, cytocompatibility and biocompatibility with absence of cytotoxicity which was evidenced from the results of MTT assay, cell adhesion and live dead assay using HaCaT cells. The results of anti-bacterial test depicted that the synthesized nanofiber forms a potent material for skin wound healing therapeutics. The in vitro drug release study for a period of 72 h revealed a sustained release pattern of Curcumin from SBA-15 incorporated PVA nanofiber. Finally, the in vivo results confirmed that SBA-15 incorporated PVA nanofiber with Curcumin showed efficient wound healing activities.

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Name: Biomedical materials (Bristol, England)
ISSN: 1748-605X
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