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Fabricating and designing a scaffold is a complex and highly challenging process in current scenario. The present study deals with the design and fabrication of electrospun SBA-15 (Santa Barbara Amorphous) incorporated PVA (Poly Vinyl Alcohol) with Curcumin which can be used as a biomimetic nanoscaffold for skin tissue engineering. Curcumin was selected due to its effectiveness in anti-microbial and anti-inflammatory properties. SBA-15 was selected for its characteristic drug carrying potential. FTIR and XRD characterizations of fabricated nanofiber expressed the interaction of PVA, SBA-15 and Curcumin. SEM results depicted that the nanofiber was highly interconnected with porous structure mimicking Extra Cellular Matrix (ECM). The nanofibrous scaffold showed higher percentage of cell migration, proliferation, cytocompatibility and biocompatibility with absence of cytotoxicity which was evidenced from the results of MTT assay, cell adhesion and live dead assay using HaCaT cells. The results of anti-bacterial test depicted that the synthesized nanofiber forms a potent material for skin wound healing therapeutics. The in vitro drug release study for a period of 72 h revealed a sustained release pattern of Curcumin from SBA-15 incorporated PVA nanofiber. Finally, the in vivo results confirmed that SBA-15 incorporated PVA nanofiber with Curcumin showed efficient wound healing activities.
This article was published in the following journal.
Name: Biomedical materials (Bristol, England)
Curcumin exhibits potent anticancer activity via various mechanisms, but its in vivo efficacy has been hampered by the poor solubility. Nanotechnology has been employed to deliver curcumin, but most o...
Health-promoting effects of curcumin are well-known; however, curcumin has a very low bioavailability due to its crystalline structure. The main objective of this study was to develop a novel green na...
A series of biodegradable amphiphilic-block segmented polyurethanes (SPUs) are designed and synthesized based on di-block and tri-block macrodiols of polycaprolactone (PCL) and polyethylene glycol (PE...
Materials and scaffolds with antimicrobial properties are of great importance in would dressing and other tissue engineering applications. The objective of the present work was to fabricate scaffolds ...
Curcumin, a controversial "panacea," has been broadly studied. Its bioactivities including antioxidant, anti-inflammatory, and especially antineoplastic activities have been documented. However, due t...
The curcuminoids curcumin, demethoxycurcumin and bisdemethoxycurcumin can be found in the rhizome of turmeric (Curcuma longa). Curcumin is widespread used for colouring foods. Based on its...
Curcumin is a commonly-used spice and food coloring. Evidence suggests that curcumin can suppress tumor initiation, promotion and metastasis in a variety of tumor cell lines. The current a...
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An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.
A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
An approach, process, or methodology which emphasizes credible evidence and the best available scientific knowledge, judiciously integrated to achieve the best possible outcomes in structural design. For example, the design of a new OUTPATIENT CLINIC might incorporate a review of published research on outpatient clinic design, decisions on similar past projects, along with interviews with staff and consumers.
Architecture, exterior and interior design, and construction of facilities other than hospitals, e.g., dental schools, medical schools, ambulatory care clinics, and specified units of health care facilities. The concept also includes architecture, design, and construction of specialized contained, controlled, or closed research environments including those of space labs and stations.
The architecture, functional design, and construction of hospitals.
Anything that breaks the skin is a wound because when the skin is broken, there's a risk of germs getting into the body and causing an infection. Follow and track Wound Care News on BioPortfolio: Wound Car...
Acne Dermatology Eczema Psoriasis Wound Care Dermatology is the medical specialty concerned with the diagnosis and treatment of skin disorders (Oxford Medical Dictionary). As well as studying how the skin works, dermatology covers...
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...