Studies on antimicrobial and wound healing applications of gauze coated with CHX-Ag hybrid NPs.

07:00 EST 1st February 2020 | BioPortfolio

Summary of "Studies on antimicrobial and wound healing applications of gauze coated with CHX-Ag hybrid NPs."

In this study, chlorhexidine (CHX)-silver (Ag) hybrid nanoparticles (NPs) coated gauze was developed, and their bactericidal effect and wound healing capacities were tested. A new method was developed to synthesise the NPs, wherein Ag nitrate mixed with sodium (Na) metaphosphate and reduced using Na borohydride. Finally, CHX digluconate was added to form the hybrid NPs. To study the antibacterial efficacy of particles, the minimal inhibition concentration and biofilm degradation capacity against Gram-positive and Gram-negative bacteria was studied using . The results indicated that the NP inhibited biofilm formation and was bactericidal as well. The gauze was doped with NPs, and its wound healing property was evaluated using mice model. Results indicated that the wound healing process was fastened by using the NPs gauze doped with NPs without the administration of antibiotics.


Journal Details

This article was published in the following journal.

Name: IET nanobiotechnology
ISSN: 1751-875X
Pages: 14-18


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