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Zn-assisted photothermal therapy for rapid bacteria-killing using biodegradable humic acid encapsulated MOFs.

07:00 EST 8th January 2020 | BioPortfolio

Summary of "Zn-assisted photothermal therapy for rapid bacteria-killing using biodegradable humic acid encapsulated MOFs."

Bacterial infection is seriously threatening human health all over the world, especially with the emergence of increasing drug-fast bacteria. It is urgent to develop a drug-free strategy to kill bacteria rapidly and efficiently. In this work, humic acid (HuA) encapsulated zeolitic imidazole framework-8 (ZIF-8) (HuA@ZIF-8) nanocomposites are synthesized by the in-situ growth of ZIF-8 on the surface of polyvinylpyrrolidone (PVP)-modified HuA. The synthesized nanocomposites possesses good photothermal effects, i.e., the temperature increased to 59.4 °C under the particle concentration of 1000 μg/mL with 10 min NIR irradiation. In addition, NIR irradiation can also control the release of Zn from the composites. The good photothermal effects originate from HuA that can effectively absorb NIR light. The controlled release of Zn is ascribed to the induced-dissociation of ZIF-8 under NIR light irradiation. The synergistic action of photothermal therapy and release of zinc ions contributes to the excellent antibacterial efficiency of HuA@ZIF-8 within a short time, i.e. 99.59 % and 99.37 % against Staphylococcus aureus and Escherichia coli with 20 min NIR irradiation, respectively. This work provides a promising strategy to develop a light-responsive platform with good biodegradability and low cost for rapid and effective sterilization.

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This article was published in the following journal.

Name: Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Pages: 110781

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